Polymersome nanoreactors for enzymatic ring-opening polymerization

M. Nallani, H.P.M. de Hoog, J.J.L.M. Cornelissen, A.R.A. Palmans, J.C.M. van Hest, R.J.M. Nolte

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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Samenvatting

Polystyrene-polyisocyanopeptide (PS-PIAT) polymersomes containing CALB in two different locations, one in the aqueous inner compartment and one in the bilayer, were investigated for enzymatic ring-opening polymerization of lactones in water. It is shown that the monomers 8-octanolactone and dodecalactone yield oligomers with this polymersome system. It is also observed that the polymerization activity is dependent on the position of the enzyme in the polymersome. SEM investigations show that the polymersome structures were destabilized during the polymerization. Further investigations show that the vesicular morphology of the polymersomes was destabilized only in the case of polymer product formation.

Originele taal-2Engels
Pagina's (van-tot)3723-3728
Aantal pagina's6
TijdschriftBiomacromolecules
Volume8
Nummer van het tijdschrift12
DOI's
StatusGepubliceerd - dec 2007

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