Polymers from functional macrolactones as potential biomaterials: Enzymatic ring opening polymerization, biodegradation, and biocompatibility

I. Meulen, van der, M. Geus, de, H. Antheunis, R. Deumens, E.A.J. Joosten, C.E. Koning, A. Heise

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

102 Citaten (Scopus)

Samenvatting

We systematically investigated a series of polymers derived from macrolactones, namely, pentadecalactone, hexadecalactone, and their unsaturated analogues ambrettolide and globalide as potential biomaterials. By enzymatic ring-opening polymerization these monomers can conveniently be polymerized to high molecular weight. The polymers are highly crystalline with melting points around 95°C for the saturated polymers and lower melting points for the unsaturated polymers (46-55°C). All polymers are nontoxic as measured by an MTT assay for metabolic cell activity of a 3T3 mouse fibroblast cell line. Degradation studies showed no hydrolytic or enzymatic degradability of the polymers, which was ascribed to the high crystallinity and hydrophobicity of the materials. The unsaturated polymers were cross-linked in the melt, yielding fully amorphous transparent materials with a gel content of 97%. © 2008 American Chemical Society.
Originele taal-2Engels
Pagina's (van-tot)3404-3410
TijdschriftBiomacromolecules
Volume9
Nummer van het tijdschrift12
DOI's
StatusGepubliceerd - 2008

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