Physical activity patterns and clusters in 1001 patients with COPD

Rafael Mesquita, Gabriele Spina, Fabio Pitta, David Donaire-Gonzalez, Brenda M. Deering, Mehul S. Patel, Katy E. Mitchell, Jennifer Alison, Arnoldus J.R. Van Gestel, Stefanie Zogg, Philippe Gagnon, Beatriz Abascal-Bolado, Barbara Vagaggini, Judith Garcia-Aymerich, Sue C. Jenkins, Elisabeth A.P.M. Romme, Samantha S.C. Kon, Paul S. Albert, Benjamin Waschki, Dinesh ShrikrishnaSally J. Singh, Nicholas S. Hopkinson, David Miedinger, Roberto P. Benzo, François Maltais, Pierluigi Paggiaro, Zoe J. McKeough, Michael I. Polkey, Kylie Hill, William D.C. Man, Christian F. Clarenbach, Nidia A. Hernandes, Daniela Savi, Sally Wootton, Karina C. Furlanetto, Li W. Cindy Ng, Anouk W. Vaes, Christine Jenkins, Peter R. Eastwood, Diana Jarreta, Anne Kirsten, Dina Brooks, David R. Hillman, Thaís Sant'Anna, Kenneth Meijer, Selina Dürr, Erica P.A. Rutten, Malcolm Kohler, Vanessa S. Probst, Ruth Tal-Singer, Esther Garcia Gil, Albertus C. den Brinker, Jörg D. Leuppi, Peter M.A. Calverley, Frank W.J.M. Smeenk, Richard W. Costello, Marco Gramm, Roger Goldstein, Miriam T.J. Groenen, Helgo Magnussen, Emiel F.M. Wouters, Richard L. Zuwallack, Oliver Amft, Henrik Watz, Martijn A. Spruit

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

34 Citaten (Scopus)
46 Downloads (Pure)


We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed. Daily physical activity measures and hourly patterns were analysed based on data from a multisensor armband. Principal component analysis (PCA) and cluster analysis were applied to physical activity measures to identify clusters. Age, body mass index (BMI), dyspnoea grade and ADO index (including age, dyspnoea and airflow obstruction) were associated with physical activity measures and hourly patterns. Five clusters were identified based on three PCA components, which accounted for 60% of variance of the data. Importantly, couch potatoes (i.e. the most inactive cluster) were characterised by higher BMI, lower FEV1, worse dyspnoea and higher ADO index compared to other clusters (p < 0.05 for all). Daily physical activity measures and hourly patterns are heterogeneous in COPD. Clusters of patients were identified solely based on physical activity data. These findings may be useful to develop interventions aiming to promote physical activity in COPD.

Originele taal-2Engels
Pagina's (van-tot)256-269
Aantal pagina's14
TijdschriftChronic Respiratory Disease
Nummer van het tijdschrift3
StatusGepubliceerd - 1 aug 2017


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