Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts

David Schönbauer, Carlo Sambiagio, Timothy Noël, Michael Schnürch (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Samenvatting

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

Originele taal-2Engels
Pagina's (van-tot)809-817
Aantal pagina's9
TijdschriftBeilstein Journal of Organic Chemistry
Volume16
DOI's
StatusGepubliceerd - 21 apr 2020

Bibliografische nota

This article is part of the thematic issue "Advances in photoredox catalysis" and is dedicated to Professor Marko D. Mihovilovic on the occasion of his 50th birthday.

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