Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels

Jie Liu; Xianwen Lou; Maaike J.G. Schotman; Patricia P. Marín San Román; Rint P. Sijbesma

doi:10.3390/gels8100615

Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels

Jie Liu, Xianwen Lou, Maaike J.G. Schotman, Patricia P. Marín San Román, Rint P. Sijbesma (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

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The design of photo-responsive supramolecular hydrogels based on coumarin dimerization and de-dimerization is described. The photo-responsive coumarin unit is chemically incorporated into an oligo(ethylene glycol) (OEG) bis-urea amphiphile that is capable of co-assembling with non-functionalized OEG amphiphile, to form supramolecular fibers. UV light with two different wavelengths (365 nm and 254 nm) is employed to induce a photo-reversible dimerization and de-dimerization process of coumarin units, respectively. The co-assembled solutions could be photo-crosslinked to induce a sol-to-gel transition through dimerization of coumarin with 365 nm UV light, and de-dimerization occurs with 254 nm UV light, to provide a weaker gel. In this system, the mechanical strength of supramolecular hydrogels can be tuned using the irradiation time, providing precise control of gelation in a supramolecular hydrogelator.

Originele taal-2	Engels
Artikelnummer	615
Aantal pagina's	13
Tijdschrift	Gels
Volume	8
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.3390/gels8100615
Status	Gepubliceerd - okt. 2022

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© 2022 by the authors.

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This research was funded by the Dutch Ministry of Education, Culture, and Science (Gravity program 024.001.035) and was supported by the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, CVON2014-27 REMAIN.

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title = "Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels",

abstract = "The design of photo-responsive supramolecular hydrogels based on coumarin dimerization and de-dimerization is described. The photo-responsive coumarin unit is chemically incorporated into an oligo(ethylene glycol) (OEG) bis-urea amphiphile that is capable of co-assembling with non-functionalized OEG amphiphile, to form supramolecular fibers. UV light with two different wavelengths (365 nm and 254 nm) is employed to induce a photo-reversible dimerization and de-dimerization process of coumarin units, respectively. The co-assembled solutions could be photo-crosslinked to induce a sol-to-gel transition through dimerization of coumarin with 365 nm UV light, and de-dimerization occurs with 254 nm UV light, to provide a weaker gel. In this system, the mechanical strength of supramolecular hydrogels can be tuned using the irradiation time, providing precise control of gelation in a supramolecular hydrogelator.",

keywords = "bis-urea amphiphile, coumarin, photo-crosslinking, supramolecular hydrogels",

author = "Jie Liu and Xianwen Lou and Schotman, {Maaike J.G.} and {Mar{\'i}n San Rom{\'a}n}, {Patricia P.} and Sijbesma, {Rint P.}",

note = "Funding Information: This research was funded by the Dutch Ministry of Education, Culture, and Science (Gravity program 024.001.035) and was supported by the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, CVON2014-27 REMAIN. ",

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AU - Marín San Román, Patricia P.

AU - Sijbesma, Rint P.

N1 - Funding Information: This research was funded by the Dutch Ministry of Education, Culture, and Science (Gravity program 024.001.035) and was supported by the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, CVON2014-27 REMAIN.

PY - 2022/10

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N2 - The design of photo-responsive supramolecular hydrogels based on coumarin dimerization and de-dimerization is described. The photo-responsive coumarin unit is chemically incorporated into an oligo(ethylene glycol) (OEG) bis-urea amphiphile that is capable of co-assembling with non-functionalized OEG amphiphile, to form supramolecular fibers. UV light with two different wavelengths (365 nm and 254 nm) is employed to induce a photo-reversible dimerization and de-dimerization process of coumarin units, respectively. The co-assembled solutions could be photo-crosslinked to induce a sol-to-gel transition through dimerization of coumarin with 365 nm UV light, and de-dimerization occurs with 254 nm UV light, to provide a weaker gel. In this system, the mechanical strength of supramolecular hydrogels can be tuned using the irradiation time, providing precise control of gelation in a supramolecular hydrogelator.

AB - The design of photo-responsive supramolecular hydrogels based on coumarin dimerization and de-dimerization is described. The photo-responsive coumarin unit is chemically incorporated into an oligo(ethylene glycol) (OEG) bis-urea amphiphile that is capable of co-assembling with non-functionalized OEG amphiphile, to form supramolecular fibers. UV light with two different wavelengths (365 nm and 254 nm) is employed to induce a photo-reversible dimerization and de-dimerization process of coumarin units, respectively. The co-assembled solutions could be photo-crosslinked to induce a sol-to-gel transition through dimerization of coumarin with 365 nm UV light, and de-dimerization occurs with 254 nm UV light, to provide a weaker gel. In this system, the mechanical strength of supramolecular hydrogels can be tuned using the irradiation time, providing precise control of gelation in a supramolecular hydrogelator.

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Photo-Crosslinked Coumarin-Containing Bis-Urea Amphiphile Hydrogels

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