Performance guarantees and optimal purification decisions for engineered proteins

T. Martagan, A. Krishnamurthy, P.A. Leland, C.T. Maravelias

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

3 Citaties (Scopus)

Uittreksel

We investigate protein purification operations conducted by biomanufacturers and pharmaceutical companies as part of their research and development efforts. Purification of these proteins involves unique challenges such as balancing the yield and purity trade-offs, dealing with uncertainty in the starting material, and estimating the impact of several interlinked decisions.We develop a Markov decision model and partition the state space into decision zones that provide managerial insights to optimize purification operations. We develop practical guidelines to quantify financial risks, and we characterize the optimal operating decisions based on specific production requirements. The optimization framework has been implemented at Aldevron, a contract biomanufacturer specializing in proteins, and has resulted in 25% reduction in the total lead times and 20% reduction in the costs of protein purification operations on average.

TaalEngels
Pagina's18-41
Aantal pagina's24
TijdschriftOperations Research
Volume66
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 1 jan 2018

Vingerafdruk

Purification
Proteins
Drug products
Guarantee
Protein
Costs
Industry

Trefwoorden

    Citeer dit

    Martagan, T. ; Krishnamurthy, A. ; Leland, P.A. ; Maravelias, C.T./ Performance guarantees and optimal purification decisions for engineered proteins. In: Operations Research. 2018 ; Vol. 66, Nr. 1. blz. 18-41
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    Martagan, T, Krishnamurthy, A, Leland, PA & Maravelias, CT 2018, 'Performance guarantees and optimal purification decisions for engineered proteins' Operations Research, vol. 66, nr. 1, blz. 18-41. DOI: 10.1287/opre.2017.1661

    Performance guarantees and optimal purification decisions for engineered proteins. / Martagan, T.; Krishnamurthy, A.; Leland, P.A.; Maravelias, C.T.

    In: Operations Research, Vol. 66, Nr. 1, 01.01.2018, blz. 18-41.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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    Martagan T, Krishnamurthy A, Leland PA, Maravelias CT. Performance guarantees and optimal purification decisions for engineered proteins. Operations Research. 2018 jan 1;66(1):18-41. Beschikbaar vanaf, DOI: 10.1287/opre.2017.1661