Samenvatting
The catalytic amidation between 2-chloro- and 2,7-dichloro-1,8-naphthyridines and primary amides bearing functional groups is reported. When Pd(OAc)2, xantphos, and K2CO3 are used, it is possible to obtain sym. as well as nonsym. 2,7-diamido-1,8-naphthyridines in 50-90% yield with good functional-group tolerance. Monoamidation of 2,7-dichloro-1,8-naphthyridine using 0.9 equiv of the amide proceeded with good selectivity compared to the formation of the diamide, but as a result of the difficult isolation of the product, isolated yields were poor to moderate (22-42%).
Originele taal-2 | Engels |
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Pagina's (van-tot) | 375-378 |
Aantal pagina's | 4 |
Tijdschrift | Journal of Organic Chemistry |
Volume | 71 |
Nummer van het tijdschrift | 1 |
DOI's | |
Status | Gepubliceerd - 2006 |