Patient-controlled analgesia: therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery

S. Indermun, Y.E. Choonara, P. Kumar, L.C. Du Toit, G. Modi, R. Luttge, V. Pillay

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

6 Citaties (Scopus)

Uittreksel

Chronic pain poses a major concern to modern medicine and is frequently undertreated, causing suffering and disability. Patient-controlled analgesia, although successful, does have limitations. Transdermal delivery is the pivot to which analgesic research in drug delivery has centralized, especially with the confines of needle phobias and associated pain related to traditional injections, and the existing limitations associated with oral drug delivery. Highlighted within is the possibility of further developing transdermal drug delivery for chronic pain treatment using iontophoresis-based microneedle array patches. A concerted effort was made to review critically all available therapies designed for the treatment of chronic pain. The drug delivery systems developed for this purpose and nondrug routes are elaborated on, in a systematic manner. Recent developments and future goals in transdermal delivery as a means to overcome the individual limitations of the aforementioned delivery routes are represented as well. The approval of patch-like devices that contain both the microelectronic-processing mechanism and the active medicament in a small portable device is still awaited by the pharmaceutical industry. This anticipated platform may provide transdermal electro-activated and electro-modulated drug delivery systems a feasible attempt in chronic pain treatment. Iontophoresis has been proven an effective mode used to administer ionized drugs in physiotherapeutic, diagnostic, and dermatological applications and may be an encouraging probability for the development of devices and aids in the treatment of chronic pain.

Originele taal-2Engels
Pagina's (van-tot)353-366
Aantal pagina's14
TijdschriftEuropean Journal of Pharmaceutical Sciences
Volume103
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - 2014

Vingerafdruk

Patient-Controlled Analgesia
Chronic Pain
Iontophoresis
Pharmaceutical Preparations
Drug Delivery Systems
Equipment and Supplies
Therapeutics
Modern 1601-history
Phobic Disorders
Drug Industry
Psychological Stress
Needles
Analgesics
Pain
Injections
Research

Citeer dit

Indermun, S. ; Choonara, Y.E. ; Kumar, P. ; Du Toit, L.C. ; Modi, G. ; Luttge, R. ; Pillay, V. / Patient-controlled analgesia : therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery. In: European Journal of Pharmaceutical Sciences. 2014 ; Vol. 103, Nr. 2. blz. 353-366.
@article{b5ee3c16977f477b9d52d6796e8d586b,
title = "Patient-controlled analgesia: therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery",
abstract = "Chronic pain poses a major concern to modern medicine and is frequently undertreated, causing suffering and disability. Patient-controlled analgesia, although successful, does have limitations. Transdermal delivery is the pivot to which analgesic research in drug delivery has centralized, especially with the confines of needle phobias and associated pain related to traditional injections, and the existing limitations associated with oral drug delivery. Highlighted within is the possibility of further developing transdermal drug delivery for chronic pain treatment using iontophoresis-based microneedle array patches. A concerted effort was made to review critically all available therapies designed for the treatment of chronic pain. The drug delivery systems developed for this purpose and nondrug routes are elaborated on, in a systematic manner. Recent developments and future goals in transdermal delivery as a means to overcome the individual limitations of the aforementioned delivery routes are represented as well. The approval of patch-like devices that contain both the microelectronic-processing mechanism and the active medicament in a small portable device is still awaited by the pharmaceutical industry. This anticipated platform may provide transdermal electro-activated and electro-modulated drug delivery systems a feasible attempt in chronic pain treatment. Iontophoresis has been proven an effective mode used to administer ionized drugs in physiotherapeutic, diagnostic, and dermatological applications and may be an encouraging probability for the development of devices and aids in the treatment of chronic pain.",
keywords = "Chronic pain, Drug transport, Electro-conductive hydrogel, Iontophoresis, Microneedle arrays, Patient-controlled analgesia, Permeation enhancers, Polymeric drug delivery systems, Transdermal drug delivery",
author = "S. Indermun and Y.E. Choonara and P. Kumar and {Du Toit}, L.C. and G. Modi and R. Luttge and V. Pillay",
year = "2014",
doi = "10.1002/jps.23829",
language = "English",
volume = "103",
pages = "353--366",
journal = "European Journal of Pharmaceutical Sciences",
issn = "0928-0987",
publisher = "Elsevier",
number = "2",

}

Patient-controlled analgesia : therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery. / Indermun, S.; Choonara, Y.E.; Kumar, P.; Du Toit, L.C.; Modi, G.; Luttge, R.; Pillay, V.

In: European Journal of Pharmaceutical Sciences, Vol. 103, Nr. 2, 2014, blz. 353-366.

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

TY - JOUR

T1 - Patient-controlled analgesia

T2 - therapeutic interventions using transdermal electro-activated and electro-modulated drug delivery

AU - Indermun, S.

AU - Choonara, Y.E.

AU - Kumar, P.

AU - Du Toit, L.C.

AU - Modi, G.

AU - Luttge, R.

AU - Pillay, V.

PY - 2014

Y1 - 2014

N2 - Chronic pain poses a major concern to modern medicine and is frequently undertreated, causing suffering and disability. Patient-controlled analgesia, although successful, does have limitations. Transdermal delivery is the pivot to which analgesic research in drug delivery has centralized, especially with the confines of needle phobias and associated pain related to traditional injections, and the existing limitations associated with oral drug delivery. Highlighted within is the possibility of further developing transdermal drug delivery for chronic pain treatment using iontophoresis-based microneedle array patches. A concerted effort was made to review critically all available therapies designed for the treatment of chronic pain. The drug delivery systems developed for this purpose and nondrug routes are elaborated on, in a systematic manner. Recent developments and future goals in transdermal delivery as a means to overcome the individual limitations of the aforementioned delivery routes are represented as well. The approval of patch-like devices that contain both the microelectronic-processing mechanism and the active medicament in a small portable device is still awaited by the pharmaceutical industry. This anticipated platform may provide transdermal electro-activated and electro-modulated drug delivery systems a feasible attempt in chronic pain treatment. Iontophoresis has been proven an effective mode used to administer ionized drugs in physiotherapeutic, diagnostic, and dermatological applications and may be an encouraging probability for the development of devices and aids in the treatment of chronic pain.

AB - Chronic pain poses a major concern to modern medicine and is frequently undertreated, causing suffering and disability. Patient-controlled analgesia, although successful, does have limitations. Transdermal delivery is the pivot to which analgesic research in drug delivery has centralized, especially with the confines of needle phobias and associated pain related to traditional injections, and the existing limitations associated with oral drug delivery. Highlighted within is the possibility of further developing transdermal drug delivery for chronic pain treatment using iontophoresis-based microneedle array patches. A concerted effort was made to review critically all available therapies designed for the treatment of chronic pain. The drug delivery systems developed for this purpose and nondrug routes are elaborated on, in a systematic manner. Recent developments and future goals in transdermal delivery as a means to overcome the individual limitations of the aforementioned delivery routes are represented as well. The approval of patch-like devices that contain both the microelectronic-processing mechanism and the active medicament in a small portable device is still awaited by the pharmaceutical industry. This anticipated platform may provide transdermal electro-activated and electro-modulated drug delivery systems a feasible attempt in chronic pain treatment. Iontophoresis has been proven an effective mode used to administer ionized drugs in physiotherapeutic, diagnostic, and dermatological applications and may be an encouraging probability for the development of devices and aids in the treatment of chronic pain.

KW - Chronic pain

KW - Drug transport

KW - Electro-conductive hydrogel

KW - Iontophoresis

KW - Microneedle arrays

KW - Patient-controlled analgesia

KW - Permeation enhancers

KW - Polymeric drug delivery systems

KW - Transdermal drug delivery

UR - http://www.scopus.com/inward/record.url?scp=84895924059&partnerID=8YFLogxK

U2 - 10.1002/jps.23829

DO - 10.1002/jps.23829

M3 - Review article

C2 - 24375381

AN - SCOPUS:84895924059

VL - 103

SP - 353

EP - 366

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

IS - 2

ER -