Optimizing the deprotection of the amine protecting p-methoxyphenyl group in an automated microreactor platform

K. Koch; B.J.A. van Weerdenburg; J.M.M. Verkade; P.J. Nieuwland; F.P.J.T. Rutjes; J.C.M. Hest, van

doi:10.1021/op900139u

Optimizing the deprotection of the amine protecting p-methoxyphenyl group in an automated microreactor platform

K. Koch, B.J.A. van Weerdenburg, J.M.M. Verkade, P.J. Nieuwland, F.P.J.T. Rutjes, J.C.M. Hest, van

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

31 Citaten (Scopus)

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Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p- methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.

Originele taal-2	Engels
Pagina's (van-tot)	1003-1006
Aantal pagina's	4
Tijdschrift	Organic Process Research & Development
Volume	13
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1021/op900139u
Status	Gepubliceerd - 18 sep. 2009
Extern gepubliceerd	Ja

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abstract = "Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p- methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.",

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AU - Hest, van, J.C.M.

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AB - Three factors (temperature, stoichiometry and reaction temperature) were investigated in continuous flow microreactors in an automated fashion for optimization of the removal of the p- methoxyphenyl (PMP) protecting group, thereby consuming only minute amounts of substrate (0.2 mg/sample). The optimal reaction conditions were also applied to a larger microreactor system, in which the corresponding free amine was obtained at a preparative scale.

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Optimizing the deprotection of the amine protecting p-methoxyphenyl group in an automated microreactor platform

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