Optimisation of the preparation and isolation of 5-amino-2,4,6-triiodoisophthalic acid dichloride

H.J.M. Gijsen; H.C.C.K. Bakel, van; W. Zwaan; L.A. Hulshof

doi:10.1021/op980055+

Optimisation of the preparation and isolation of 5-amino-2,4,6-triiodoisophthalic acid dichloride

H.J.M. Gijsen, H.C.C.K. Bakel, van, W. Zwaan, L.A. Hulshof

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A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design.

Originele taal-2	Engels
Pagina's (van-tot)	38-43
Aantal pagina's	7
Tijdschrift	Organic Process Research & Development
Volume	3
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1021/op980055+
Status	Gepubliceerd - 1999

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abstract = "A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design.",

author = "H.J.M. Gijsen and {Bakel, van}, H.C.C.K. and W. Zwaan and L.A. Hulshof",

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doi = "10.1021/op980055+",

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AU - Bakel, van, H.C.C.K.

AU - Zwaan, W.

AU - Hulshof, L.A.

PY - 1999

Y1 - 1999

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AB - A scaleable process for the chlorination of 5-amino-2,4,6-triiodoisophthalic acid to the corresponding acid chloride, a building block for the synthesis of iodinated X-ray contrast agents, has been developed. Two dimeric byproducts have been isolated and assigned structures consistent with an amide and an anhydride. Hydrolysis of the N-sulfinyl intermediate and simultaneous crystallisation of the phthalic acid chloride have been optimised by applying fractional factorial design.

U2 - 10.1021/op980055+

DO - 10.1021/op980055+

M3 - Article

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Optimisation of the preparation and isolation of 5-amino-2,4,6-triiodoisophthalic acid dichloride

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