On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue

S. Turco, I. Tardy, P.J.A. Frinking, H. Wijkstra, M. Mischi

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Uittreksel

Cancer growth requires angiogenesis; imaging of angiogenesis may thus improve cancer diagnostics and therapy monitoring. Dynamic contrast enhanced ultrasound (DCE-US) permits imaging angiogenesis at the molecular level by using novel targeted ultrasound contrast agents (tUCA). These agents consist of functionalized microbubbles obtained by engineering their shell with targeting ligands able to bind specific biomarkers, over-expressed in tumor angiogenic vasculature. Quantification of binding may thus provide an indirect way of quantifying angiogenesis. Recently, we proposed the first-pass binding (FPB) model to describe the binding kinetics of tUCA. Fitting DCE-US time-intensity curves (TICs) by the FPB model enables quantification of binding by the estimation of the binding rate Kb. After showing the feasibility of the method for angiogenesis imaging in prostate-tumor bearing rats, and performing a preliminary validation for anti-angiogenesis therapy monitoring in colon cancer-bearing mice, in this work we investigated the validity of the proposed model by comparing Kb estimates in rats injected with non-targeted UCAs (Sonovue) and tUCAs (BR55). Significantly lower values of Kb were found for Sonovue compared to BR55, with no significant difference between cancer and healthy prostate for Sonovue.

TaalEngels
Titel2017 IEEE International Ultrasonics Symposium (IUS)
Plaats van productiePiscataway
UitgeverijInstitute of Electrical and Electronics Engineers (IEEE)
Aantal pagina's4
ISBN van elektronische versie9781538633830
DOI's
StatusGepubliceerd - 31 okt 2017
Evenement2017 IEEE International Ultrasonics Symposium - e Omni Shoreham Hotel, Washington, Verenigde Staten van Amerika
Duur: 6 sep 20179 sep 2017
http://ewh.ieee.org/conf/ius/2017/

Congres

Congres2017 IEEE International Ultrasonics Symposium
Verkorte titelIEEE iUS
LandVerenigde Staten van Amerika
StadWashington
Periode6/09/179/09/17
Internet adres

Trefwoorden

    Citeer dit

    Turco, S., Tardy, I., Frinking, P. J. A., Wijkstra, H., & Mischi, M. (2017). On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue. In 2017 IEEE International Ultrasonics Symposium (IUS) [8091975] Piscataway: Institute of Electrical and Electronics Engineers (IEEE). DOI: 10.1109/ULTSYM.2017.8092723, 10.1109/ULTSYM.2017.8091975
    Turco, S. ; Tardy, I. ; Frinking, P.J.A. ; Wijkstra, H. ; Mischi, M./ On the validity of the first-pass binding model for quantitative ultrasound molecular imaging : Comparison between BR55 and Sonovue. 2017 IEEE International Ultrasonics Symposium (IUS) . Piscataway : Institute of Electrical and Electronics Engineers (IEEE), 2017.
    @inproceedings{ede3ce78150a47bd89dfe2fb89186d7f,
    title = "On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue",
    abstract = "Cancer growth requires angiogenesis; imaging of angiogenesis may thus improve cancer diagnostics and therapy monitoring. Dynamic contrast enhanced ultrasound (DCE-US) permits imaging angiogenesis at the molecular level by using novel targeted ultrasound contrast agents (tUCA). These agents consist of functionalized microbubbles obtained by engineering their shell with targeting ligands able to bind specific biomarkers, over-expressed in tumor angiogenic vasculature. Quantification of binding may thus provide an indirect way of quantifying angiogenesis. Recently, we proposed the first-pass binding (FPB) model to describe the binding kinetics of tUCA. Fitting DCE-US time-intensity curves (TICs) by the FPB model enables quantification of binding by the estimation of the binding rate Kb. After showing the feasibility of the method for angiogenesis imaging in prostate-tumor bearing rats, and performing a preliminary validation for anti-angiogenesis therapy monitoring in colon cancer-bearing mice, in this work we investigated the validity of the proposed model by comparing Kb estimates in rats injected with non-targeted UCAs (Sonovue) and tUCAs (BR55). Significantly lower values of Kb were found for Sonovue compared to BR55, with no significant difference between cancer and healthy prostate for Sonovue.",
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    Turco, S, Tardy, I, Frinking, PJA, Wijkstra, H & Mischi, M 2017, On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue. in 2017 IEEE International Ultrasonics Symposium (IUS) ., 8091975, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, 2017 IEEE International Ultrasonics Symposium , Washington, Verenigde Staten van Amerika, 6/09/17. DOI: 10.1109/ULTSYM.2017.8092723, 10.1109/ULTSYM.2017.8091975

    On the validity of the first-pass binding model for quantitative ultrasound molecular imaging : Comparison between BR55 and Sonovue. / Turco, S.; Tardy, I.; Frinking, P.J.A.; Wijkstra, H.; Mischi, M.

    2017 IEEE International Ultrasonics Symposium (IUS) . Piscataway : Institute of Electrical and Electronics Engineers (IEEE), 2017. 8091975.

    Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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    AB - Cancer growth requires angiogenesis; imaging of angiogenesis may thus improve cancer diagnostics and therapy monitoring. Dynamic contrast enhanced ultrasound (DCE-US) permits imaging angiogenesis at the molecular level by using novel targeted ultrasound contrast agents (tUCA). These agents consist of functionalized microbubbles obtained by engineering their shell with targeting ligands able to bind specific biomarkers, over-expressed in tumor angiogenic vasculature. Quantification of binding may thus provide an indirect way of quantifying angiogenesis. Recently, we proposed the first-pass binding (FPB) model to describe the binding kinetics of tUCA. Fitting DCE-US time-intensity curves (TICs) by the FPB model enables quantification of binding by the estimation of the binding rate Kb. After showing the feasibility of the method for angiogenesis imaging in prostate-tumor bearing rats, and performing a preliminary validation for anti-angiogenesis therapy monitoring in colon cancer-bearing mice, in this work we investigated the validity of the proposed model by comparing Kb estimates in rats injected with non-targeted UCAs (Sonovue) and tUCAs (BR55). Significantly lower values of Kb were found for Sonovue compared to BR55, with no significant difference between cancer and healthy prostate for Sonovue.

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    Turco S, Tardy I, Frinking PJA, Wijkstra H, Mischi M. On the validity of the first-pass binding model for quantitative ultrasound molecular imaging: Comparison between BR55 and Sonovue. In 2017 IEEE International Ultrasonics Symposium (IUS) . Piscataway: Institute of Electrical and Electronics Engineers (IEEE). 2017. 8091975. Beschikbaar vanaf, DOI: 10.1109/ULTSYM.2017.8092723, 10.1109/ULTSYM.2017.8091975