TY - JOUR
T1 - On complex coacervate core micelles
T2 - Structure-function perspectives
AU - Magana, Jose Rodrigo
AU - Sproncken, Christian C.M.
AU - Voets, Ilja K.
PY - 2020/9
Y1 - 2020/9
N2 - The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, such as gelation, catalysis, nanoparticle synthesis, and sensing, is increasing. In this review, we discuss recent studies on the functional roles that C3Ms can fulfil in these and other fields, focusing on emerging structure-function relations and remaining knowledge gaps.
AB - The co-assembly of ionic-neutral block copolymers with oppositely charged species produces nanometric colloidal complexes, known, among other names, as complex coacervates core micelles (C3Ms). C3Ms are of widespread interest in nanomedicine for controlled delivery and release, whilst research activity into other application areas, such as gelation, catalysis, nanoparticle synthesis, and sensing, is increasing. In this review, we discuss recent studies on the functional roles that C3Ms can fulfil in these and other fields, focusing on emerging structure-function relations and remaining knowledge gaps.
KW - Co-assembly
KW - Complex coacervate core micelle
KW - Interpolyelectrolyte complex
KW - Polyelectrolytes
KW - Polyion complex
KW - Polyplex
KW - Protein-polymer complex
KW - Structure-function relations
UR - http://www.scopus.com/inward/record.url?scp=85091340089&partnerID=8YFLogxK
U2 - 10.3390/POLYM12091953
DO - 10.3390/POLYM12091953
M3 - Review article
C2 - 32872312
AN - SCOPUS:85091340089
SN - 2073-4360
VL - 12
JO - Polymers
JF - Polymers
IS - 9
M1 - 1953
ER -