Nuclear elemental analyses with a cyclotron on biomedical samples

J.A. Quaedackers, M.J.A. Voigt, de, P.H.A. Mutsaers, J.J.M. de Goeij, G.J. Vusse, van der

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    The Eindhoven scanning proton microprobe enables the determination of the ion content of heart tissue on a sub-cellular scale. It is shown that intra-cellular elemental concentrations can be determined. Measurements are carried out for physiological and patho-physiological rat heart muscle tissue. Important alterations in Na and K concentrations are reported as measured with PIXE, RBS and NFS techniques employing a variable energy cyclotron (3–30 MeV). However, quantitative intra-cellular determinations are hampered by the presence of extra-cellular space (ECS). For this purpose, cobaltic ethylene-diamine-tetra-acetic-acid (Co(III)EDTA) was used as an exogenic ECS marker. The intra-cellular ion concentrations of normoxic tissue after correction for the ECS agree well with the literature values.
    Originele taal-2Engels
    Pagina's (van-tot)252-257
    Aantal pagina's6
    TijdschriftNuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
    Nummer van het tijdschrift1-4
    StatusGepubliceerd - 1999

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