Samenvatting
Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with e-caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly(L-lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring-opening polymerization. The successful synthesis of the heterografted comb-shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 736-746 |
Tijdschrift | Macromolecular Chemistry and Physics |
Volume | 210 |
Nummer van het tijdschrift | 9 |
DOI's | |
Status | Gepubliceerd - 2009 |