Nowadays, advanced technologies for rational use of energy in dwellings have aroused a considerable interest. In cold countries huge amounts of heat and moisture are wasted through the air infiltration due to the large difference between indoor and outdoor temperatures. In this work, an advanced adsorption approach to heat and moisture recuperation in ventilation, called VentireC, is suggested. In this approach, the moisture and sensible heat from outgoing air are absorbed on the adsorbent and heat storing beds and then withdrawn into the inflowing outdoor air, thus, maintaining the indoor temperature and humidity balance. Thermal coupling between two adsorbent beds, which work out of phase, allows latent and sensible loads to be managed separately to enhance the humidity recuperation. For harmonizing the adsorbent properties with the operating conditions of the VentireC process, the requirements for optimal sorbents are formulated based on the thermodynamic analysis of the process. New sorbents based on LiCl incorporated in four matrices with the various mesoporous structure are synthesized and investigated. The water sorption/desorption equilibrium for the most promising sorbent is reported. This composite exchanges over 0.5 g-H2O/g under a typical VentireC cycle, which is promising for effective heat and moisture regeneration.