New compound classes: Protein–protein interactions

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

3 Citaten (Scopus)
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Samenvatting

Protein-protein interactions (PPIs) are one of the most promising new targets in drug discovery. With estimates between 300,000 and 650,000 in human physiology, targeted modulation of PPIs would tremendously extend the "druggable" genome. In fact, in every disease a wealth of potentially addressable PPIs can be found making pharmacological intervention based on PPI modulators in principle a generally applicable technology. An impressing number of success stories in small-molecule PPI inhibition and natural-product PPI stabilization increasingly encourage academia and industry to invest in PPI modulation. In this chapter examples of both inhibition as well as stabilization of PPIs are reviewed including some of the technologies which has been used for their identification
Originele taal-2Engels
TitelHandbook of Experimental Pharmacology
RedacteurenU. Nielsch, U. Fuhrmann, S. Jaroch
Plaats van productieBerlin
UitgeverijSpringer
Pagina's125-138
Aantal pagina's14
Volume232
ISBN van elektronische versie978-3-319-28914-4
ISBN van geprinte versie978-3-319-28912-0
DOI's
StatusGepubliceerd - 1 apr 2016

Publicatie series

NaamHandbook of experimental pharmacology
UitgeverijSpringer
Volume232
ISSN van geprinte versie0171-2004

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