Multivalent supramolecular dendrimer-based drugs

S. Galeazzi; T.M. Hermans; M. Paolino; M. Anzini; L. Mennuni; A. Giordani; G. Caselli; F. Makovec; E.W. Meijer; S. Vomero; A. Cappelli

doi:10.1021/bm901055a

Multivalent supramolecular dendrimer-based drugs

S. Galeazzi, T.M. Hermans, M. Paolino, M. Anzini, L. Mennuni, A. Giordani, G. Caselli, F. Makovec, E.W. Meijer, S. Vomero, A. Cappelli

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

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Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)64] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT3) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.

Originele taal-2	Engels
Pagina's (van-tot)	182-186
Aantal pagina's	4
Tijdschrift	Biomacromolecules
Volume	11
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1021/bm901055a
Status	Gepubliceerd - 2010

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abstract = "Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)64] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT3) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.",

author = "S. Galeazzi and T.M. Hermans and M. Paolino and M. Anzini and L. Mennuni and A. Giordani and G. Caselli and F. Makovec and E.W. Meijer and S. Vomero and A. Cappelli",

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AU - Galeazzi, S.

AU - Hermans, T.M.

AU - Paolino, M.

AU - Anzini, M.

AU - Mennuni, L.

AU - Giordani, A.

AU - Caselli, G.

AU - Makovec, F.

AU - Meijer, E.W.

AU - Vomero, S.

AU - Cappelli, A.

PY - 2010

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N2 - Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)64] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT3) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.

AB - Supramolecular complexes consisting of a hydrophobic dendrimer host [DAB-dendr-(NHCONH-Ad)64] as well as solubilizing and bioactive guest molecules have been synthesized using a noncovalent approach. The guest-host supramolecular assembly is first preassembled in chloroform and transferred via the neat phase to aqueous solution. The bioactive guest molecules can bind to a natural (serotonin 5-HT3) receptor with nanomolar affinity as well as to the synthetic dendrimer receptor in aqueous solution, going toward a dynamic multivalent supramolecular construct capable of adapting itself to a multimeric receptor motif.

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JF - Biomacromolecules

IS - 1

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Multivalent supramolecular dendrimer-based drugs

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