Monitoring of anti-angiogenic therapy by quantitative ultrasound molecular imaging

S. Turco, Ahmed El Kaffas, Jianhua Zhou, Juergen K. Willmann, H. Wijkstra, M. Mischi

Onderzoeksoutput: Bijdrage aan congresAbstractAcademic

Samenvatting

Cancer growth and development requires angiogenesis, i.e., the formation of a blood supply to feed the tumor and enable metastatic spreading [1]. In cancer angiogenesis, pro-angiogenic factors are secreted to trigger the growth of new blood vessels and the recruitment of pre-existing vessels from surrounding tissue. The resulting vasculature is characterized by a chaotic network of abnormal micro-vessels exhibiting increased tortuosity and permeability, irregular diameters and branching, and arterio-venous shunting. This has led to a shift both in cancer diagnostics, whereby several in-vivo non-invasive imaging methods have been developed to assess the structural, functional, and molecular changes occurring due to cancer angiogenesis [2], and in cancer therapeutics, with the development of novel drugs aimed at inhibiting angiogenic processes and/or disrupting angiogenic tumor vasculature [3]
Originele taal-2Engels
Pagina's97-100
Aantal pagina's4
StatusGepubliceerd - 2017
Evenement22nd European Symposium on Ultrasound Contrast Imaging, January 19-20, 2017, Rotterdam, The Netherlands - Rotterdam, Nederland
Duur: 19 jan 201720 jan 2017

Congres

Congres22nd European Symposium on Ultrasound Contrast Imaging, January 19-20, 2017, Rotterdam, The Netherlands
LandNederland
StadRotterdam
Periode19/01/1720/01/17

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