Modeling regulation of vascular tone following muscle contraction: model development, validation and global sensitivity analysis

J.M.T. Keijsers, C.A.D. Leguy, A.J. Narracott, J. Rittweger, F.N. van de Vosse, W. Huberts

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

2 Citaten (Scopus)
35 Downloads (Pure)


In this study the regulation of vascular tone inducing the blood flow increase at the onset of exercise is examined. Therefore, our calf circulation model was extended with a regulation model to simulate changes in vascular tone depending on myogenic, metabolic and baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it was concluded that metabolic activation caused the flow increase shortly after muscle contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and baroreflex activation. Based on a sensitivity analysis the myogenic gain was identified as most important parameter.
Originele taal-2Engels
Pagina's (van-tot)143-159
Aantal pagina's17
TijdschriftJournal of Computational Science
Vroegere onlinedatum23 apr 2017
StatusGepubliceerd - jan 2018


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