Modeling cardiac growth: an alternative approach

N.C.J. van Osta, L. van der Donk, Emanuele Rondanina, Peter Bovendeerd

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

3 Citaten (Scopus)
1 Downloads (Pure)

Samenvatting

Models of cardiac growth might assist in clinical decision
making, in particular for long-term prognosis of the effect of interventions.
Most growth models strictly enforce the amount and direction
of volume change and prevent runaway growth by limiting maximum
growth. These assumptions have been questioned. We propose an alternative
model for cardiac growth, in which the actual volume change of
a tissue element is determined by the desired volume change in that
element and the degree to which this change is resisted by the surrounding
tissue. The model was evaluated on its ability to reproduce a stable
healthy left ventricular configuration under normal hemodynamic load.
A homeostatic equilibrium state could not be obtained, which might be
due to limitations in the mechanics model or an inadequate stimuluseffect
relation in the growth model. Still, the basic idea underlying the
model could be an interesting alternative to current growth models.
Originele taal-2Engels
TitelFunctional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings
RedacteurenYves Coudière, Nejib Zemzemi, Valéry Ozenne, Edward Vigmond
Plaats van productieCham
UitgeverijSpringer Nature
Pagina's258-265
Aantal pagina's8
ISBN van elektronische versie978-3-030-21949-9
ISBN van geprinte versie978-3-030-21948-2
DOI's
StatusGepubliceerd - 2019

Publicatie series

NaamLecture Notes in Computer Science
UitgeverijSpringerLink
Volume11504

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