This article is dedicated to the remembrance of one of the coauthors, Prof. Dr. L.A. (Bert) Hulshof, who passed away recently. In his work, at DSM and at Eindhoven University of Technology, Professor Bert Hulshof made many original and creative contributions to the field of Fine Chemical Process Development. In his work, Bert very successfully and systematically combined complex organic chemistry, catalysis and process technology. His systematic approach paved the way for efficient industrial scale production of many complex organic products. Bert's work on the application of microwave technology in chemical synthesis is groundbreaking. In this field he was a true pioneer.