Microvascular dysfunction is associated with worse cognitive performance the Maastricht study

Sytze P. Rensma, Thomas T. van Sloten (Corresponding author), Alfons J.H.M. Houben, Sebastian Koehler, Martin P.J. van Boxtel, Tos T.J.M. Berendschot, Jacobus F.A. Jansen, Frans R.J. Verhey, Abraham A. Kroon, Annemarie Koster, Walter H. Backes, Nicolaas Schaper, Geert-Jan Dinant, Casper G. Schalkwijk, Ronald M.A. Henry, Elze M.L. Wolfs, Mike J.A. van Heumen, Miranda T. Schram, Coen D.A. Stehouwer

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5±8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized β, −0.087 [95% CI, −0.127 to −0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted β-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1–3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.
Originele taal-2Engels
Pagina's (van-tot)237-245
Aantal pagina's9
TijdschriftHypertension
Volume75
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - jan 2020

Citeer dit

Rensma, S. P., van Sloten, T. T., Houben, A. J. H. M., Koehler, S., van Boxtel, M. P. J., Berendschot, T. T. J. M., ... Stehouwer, C. D. A. (2020). Microvascular dysfunction is associated with worse cognitive performance the Maastricht study. Hypertension, 75(1), 237-245. https://doi.org/10.1161/HYPERTENSIONAHA.119.13023
Rensma, Sytze P. ; van Sloten, Thomas T. ; Houben, Alfons J.H.M. ; Koehler, Sebastian ; van Boxtel, Martin P.J. ; Berendschot, Tos T.J.M. ; Jansen, Jacobus F.A. ; Verhey, Frans R.J. ; Kroon, Abraham A. ; Koster, Annemarie ; Backes, Walter H. ; Schaper, Nicolaas ; Dinant, Geert-Jan ; Schalkwijk, Casper G. ; Henry, Ronald M.A. ; Wolfs, Elze M.L. ; van Heumen, Mike J.A. ; Schram, Miranda T. ; Stehouwer, Coen D.A. / Microvascular dysfunction is associated with worse cognitive performance the Maastricht study. In: Hypertension. 2020 ; Vol. 75, Nr. 1. blz. 237-245.
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abstract = "Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5±8.2; 48.9{\%} women; 26.5{\%} type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized β, −0.087 [95{\%} CI, −0.127 to −0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted β-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1–3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.",
keywords = "blood pressure, cerebral small vessel disease, cognition, dilation, hyperemia, hypertension, microcirculation",
author = "Rensma, {Sytze P.} and {van Sloten}, {Thomas T.} and Houben, {Alfons J.H.M.} and Sebastian Koehler and {van Boxtel}, {Martin P.J.} and Berendschot, {Tos T.J.M.} and Jansen, {Jacobus F.A.} and Verhey, {Frans R.J.} and Kroon, {Abraham A.} and Annemarie Koster and Backes, {Walter H.} and Nicolaas Schaper and Geert-Jan Dinant and Schalkwijk, {Casper G.} and Henry, {Ronald M.A.} and Wolfs, {Elze M.L.} and {van Heumen}, {Mike J.A.} and Schram, {Miranda T.} and Stehouwer, {Coen D.A.}",
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pages = "237--245",
journal = "Hypertension",
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number = "1",

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Rensma, SP, van Sloten, TT, Houben, AJHM, Koehler, S, van Boxtel, MPJ, Berendschot, TTJM, Jansen, JFA, Verhey, FRJ, Kroon, AA, Koster, A, Backes, WH, Schaper, N, Dinant, G-J, Schalkwijk, CG, Henry, RMA, Wolfs, EML, van Heumen, MJA, Schram, MT & Stehouwer, CDA 2020, 'Microvascular dysfunction is associated with worse cognitive performance the Maastricht study', Hypertension, vol. 75, nr. 1, blz. 237-245. https://doi.org/10.1161/HYPERTENSIONAHA.119.13023

Microvascular dysfunction is associated with worse cognitive performance the Maastricht study. / Rensma, Sytze P.; van Sloten, Thomas T. (Corresponding author); Houben, Alfons J.H.M.; Koehler, Sebastian; van Boxtel, Martin P.J.; Berendschot, Tos T.J.M.; Jansen, Jacobus F.A.; Verhey, Frans R.J.; Kroon, Abraham A.; Koster, Annemarie; Backes, Walter H.; Schaper, Nicolaas; Dinant, Geert-Jan; Schalkwijk, Casper G.; Henry, Ronald M.A.; Wolfs, Elze M.L.; van Heumen, Mike J.A.; Schram, Miranda T.; Stehouwer, Coen D.A.

In: Hypertension, Vol. 75, Nr. 1, 01.2020, blz. 237-245.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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T1 - Microvascular dysfunction is associated with worse cognitive performance the Maastricht study

AU - Rensma, Sytze P.

AU - van Sloten, Thomas T.

AU - Houben, Alfons J.H.M.

AU - Koehler, Sebastian

AU - van Boxtel, Martin P.J.

AU - Berendschot, Tos T.J.M.

AU - Jansen, Jacobus F.A.

AU - Verhey, Frans R.J.

AU - Kroon, Abraham A.

AU - Koster, Annemarie

AU - Backes, Walter H.

AU - Schaper, Nicolaas

AU - Dinant, Geert-Jan

AU - Schalkwijk, Casper G.

AU - Henry, Ronald M.A.

AU - Wolfs, Elze M.L.

AU - van Heumen, Mike J.A.

AU - Schram, Miranda T.

AU - Stehouwer, Coen D.A.

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N2 - Microvascular dysfunction may be associated with worse cognitive performance. Most previous studies did not adjust for important confounders, evaluated only individual measures of microvascular dysfunction, and showed inconsistent results. We evaluated the association between a comprehensive set of measures of microvascular dysfunction and cognitive performance in the population-based Maastricht Study. We used cross-sectional data including 3011 participants (age 59.5±8.2; 48.9% women; 26.5% type 2 diabetes mellitus [oversampled by design]). Measures of microvascular dysfunction included magnetic resonance imaging features of cerebral small vessel disease, plasma biomarkers of microvascular dysfunction, albuminuria, flicker light-induced retinal arteriolar and venular dilation response and heat-induced skin hyperemia. These measures were summarized into a microvascular dysfunction composite score. Cognitive domains assessed were memory, processing speed, and executive function. A cognitive function score was calculated as the sum of the scores on these 3 cognitive domains. The microvascular dysfunction score was associated with a worse cognitive function score (standardized β, −0.087 [95% CI, −0.127 to −0.047]), independent of age, education level, sex, type 2 diabetes mellitus, smoking, alcohol use, hypertension, total/HDL (high-density lipoprotein) cholesterol ratio, triglycerides, lipid-modifying medication, prior cardiovascular disease, depression and plasma biomarkers of low-grade inflammation. The fully adjusted β-coefficient of the association between the microvascular dysfunction score and the cognitive function score was equivalent to 2 (range, 1–3) years of aging for each SD higher microvascular dysfunction score. The microvascular dysfunction score was associated with worse memory and processing speed but not with worse executive function. The present study shows that microvascular dysfunction is associated with worse cognitive performance.

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KW - cerebral small vessel disease

KW - cognition

KW - dilation

KW - hyperemia

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