Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches

Jelle J.F. Sleeboom, Hossein Eslami Amirabadi, Poornima Nair, Cecilia M. Sahlgren, Jaap M.J. Den Toonder

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12 Citaties (Scopus)

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Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging, but essential to understanding metastasis. Recently, cancer-on-a-chip models have emerged as a tool to study the tumor microenvironment and its role in metastasis. These models are based on microfluidic chips and contain small chambers for cell culture, enabling control over local gradients, fluid flow, tissue mechanics, and composition of the local environment. Here, we review the recent contributions of cancer-on-a-chip models to our understanding of the role of the tumor microenvironment in the onset of metastasis, and provide an outlook for future applications of this emerging technology.

TaalEngels
Artikelnummer033100
TijdschriftDisease Models & Mechanisms
Volume11
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 1 mrt 2018

Vingerafdruk

Tumor Microenvironment
Tumors
Neoplasm Metastasis
Neoplasms
Mechanics
Cues
Microfluidics
Tissue
Fluid mechanics
Extracellular Matrix
Chemical analysis
Cell culture
Cell Culture Techniques
Flow of fluids
Technology
Population

Trefwoorden

    Citeer dit

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    title = "Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches",
    abstract = "Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging, but essential to understanding metastasis. Recently, cancer-on-a-chip models have emerged as a tool to study the tumor microenvironment and its role in metastasis. These models are based on microfluidic chips and contain small chambers for cell culture, enabling control over local gradients, fluid flow, tissue mechanics, and composition of the local environment. Here, we review the recent contributions of cancer-on-a-chip models to our understanding of the role of the tumor microenvironment in the onset of metastasis, and provide an outlook for future applications of this emerging technology.",
    keywords = "Cancer, Cancer-on-a-chip, Metastasis, Microfluidics, Tumor microenvironment",
    author = "Sleeboom, {Jelle J.F.} and Amirabadi, {Hossein Eslami} and Poornima Nair and Sahlgren, {Cecilia M.} and {Den Toonder}, {Jaap M.J.}",
    year = "2018",
    month = "3",
    day = "1",
    doi = "10.1242/dmm.033100",
    language = "English",
    volume = "11",
    journal = "Disease Models & Mechanisms",
    issn = "1754-8403",
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    Metastasis in context : modeling the tumor microenvironment with cancer-on-a-chip approaches. / Sleeboom, Jelle J.F.; Amirabadi, Hossein Eslami; Nair, Poornima; Sahlgren, Cecilia M.; Den Toonder, Jaap M.J.

    In: Disease Models & Mechanisms, Vol. 11, Nr. 3, 033100, 01.03.2018.

    Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenAcademicpeer review

    TY - JOUR

    T1 - Metastasis in context

    T2 - Disease Models & Mechanisms

    AU - Sleeboom,Jelle J.F.

    AU - Amirabadi,Hossein Eslami

    AU - Nair,Poornima

    AU - Sahlgren,Cecilia M.

    AU - Den Toonder,Jaap M.J.

    PY - 2018/3/1

    Y1 - 2018/3/1

    N2 - Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging, but essential to understanding metastasis. Recently, cancer-on-a-chip models have emerged as a tool to study the tumor microenvironment and its role in metastasis. These models are based on microfluidic chips and contain small chambers for cell culture, enabling control over local gradients, fluid flow, tissue mechanics, and composition of the local environment. Here, we review the recent contributions of cancer-on-a-chip models to our understanding of the role of the tumor microenvironment in the onset of metastasis, and provide an outlook for future applications of this emerging technology.

    AB - Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process. Cues from the tumor microenvironment, such as the biochemical composition, cellular population, extracellular matrix, and tissue (fluid) mechanics, have been indicated to play a pivotal role in the onset of metastasis. Dissecting the role of these cues from the tumor microenvironment in a controlled manner is challenging, but essential to understanding metastasis. Recently, cancer-on-a-chip models have emerged as a tool to study the tumor microenvironment and its role in metastasis. These models are based on microfluidic chips and contain small chambers for cell culture, enabling control over local gradients, fluid flow, tissue mechanics, and composition of the local environment. Here, we review the recent contributions of cancer-on-a-chip models to our understanding of the role of the tumor microenvironment in the onset of metastasis, and provide an outlook for future applications of this emerging technology.

    KW - Cancer

    KW - Cancer-on-a-chip

    KW - Metastasis

    KW - Microfluidics

    KW - Tumor microenvironment

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    U2 - 10.1242/dmm.033100

    DO - 10.1242/dmm.033100

    M3 - Review article

    VL - 11

    JO - Disease Models & Mechanisms

    JF - Disease Models & Mechanisms

    SN - 1754-8403

    IS - 3

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