Mems actuation promotes in vitro brain-on-chip maturation

Alex Bastiaens, Gulden Akcay, Maaike Fransen, Sijia Xie, Regina Luttge

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

1 Citaat (Scopus)

Samenvatting

We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.

Originele taal-2Engels
TitelMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
UitgeverijChemical and Biological Microsystems Society
Pagina's957-958
Aantal pagina's2
ISBN van elektronische versie9781733419017
StatusGepubliceerd - 2020
Evenement24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duur: 4 okt 20209 okt 2020

Congres

Congres24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
StadVirtual, Online
Periode4/10/209/10/20

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