Mems actuation promotes in vitro brain-on-chip maturation

Alex Bastiaens; Gulden Akcay; Maaike Fransen; Sijia Xie; Regina Luttge

Mems actuation promotes in vitro brain-on-chip maturation

Alex Bastiaens, Gulden Akcay, Maaike Fransen, Sijia Xie, Regina Luttge

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

Samenvatting

We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.

Originele taal-2	Engels
Titel	MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Uitgeverij	Royal Society of Chemistry
Pagina's	957-958
Aantal pagina's	2
ISBN van elektronische versie	9781733419017
Status	Gepubliceerd - 2020
Evenement	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online Duur: 4 okt. 2020 → 9 okt. 2020

Congres

Congres	24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Stad	Virtual, Online
Periode	4/10/20 → 9/10/20

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@inproceedings{f6b5bac388234520b4a02f38916faa8a,

title = "Mems actuation promotes in vitro brain-on-chip maturation",

abstract = "We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.",

keywords = "Brain-on-Chip, Calcium imaging, Mechanical stimulation, Mechanotransduction, SH-SY5Y",

author = "Alex Bastiaens and Gulden Akcay and Maaike Fransen and Sijia Xie and Regina Luttge",

year = "2020",

language = "English",

pages = "957--958",

booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Royal Society of Chemistry",

address = "United Kingdom",

note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",

}

Bastiaens, A , Akcay, G, Fransen, M, Xie, S & Luttge, R 2020, Mems actuation promotes in vitro brain-on-chip maturation. in MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences., W5-533.e, Royal Society of Chemistry, blz. 957-958, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, Virtual, Online, 4/10/20.

Mems actuation promotes in vitro brain-on-chip maturation. / Bastiaens, Alex ; Akcay, Gulden; Fransen, Maaike et al.
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Royal Society of Chemistry, 2020. blz. 957-958 W5-533.e.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

TY - GEN

T1 - Mems actuation promotes in vitro brain-on-chip maturation

AU - Bastiaens, Alex

AU - Akcay, Gulden

AU - Fransen, Maaike

AU - Xie, Sijia

AU - Luttge, Regina

PY - 2020

Y1 - 2020

N2 - We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.

AB - We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.

KW - Brain-on-Chip

KW - Calcium imaging

KW - Mechanical stimulation

KW - Mechanotransduction

KW - SH-SY5Y

UR - http://www.scopus.com/inward/record.url?scp=85098247124&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85098247124

SP - 957

EP - 958

BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Royal Society of Chemistry

T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020

Y2 - 4 October 2020 through 9 October 2020

ER -

Mems actuation promotes in vitro brain-on-chip maturation

Samenvatting

Congres

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