TY - JOUR
T1 - Mechanical properties of brain tissue by indentation : interregional variation
AU - Dommelen, van, J.A.W.
AU - Sande, van der, T.P.J.
AU - Hrapko, M.
AU - Peters, G.W.M.
PY - 2010
Y1 - 2010
N2 - Although many studies on the mechanical properties of brain tissue exist, some controversy concerning the possible differences in mechanical properties of white and gray matter tissue remains. Indentation experiments are conducted on white and gray matter tissue of various regions of the cerebrum and on tissue from the thalamus and the midbrain to study interregional differences. An advantage of indentation, when compared to standard rheological tests as often used for the characterization of brain tissue, is that it is a local test, requiring only a small volume of tissue to be homogeneous. Indentation tests are performed at different speeds and the force relaxation after a step indent is measured as well. White matter tissue is found to be stiffer than gray matter and to show more variation in response between different samples which is consistent with structural differences between white matter and gray matter. In addition to differences between white matter and gray matter, also different regions of brain tissue are compared.
AB - Although many studies on the mechanical properties of brain tissue exist, some controversy concerning the possible differences in mechanical properties of white and gray matter tissue remains. Indentation experiments are conducted on white and gray matter tissue of various regions of the cerebrum and on tissue from the thalamus and the midbrain to study interregional differences. An advantage of indentation, when compared to standard rheological tests as often used for the characterization of brain tissue, is that it is a local test, requiring only a small volume of tissue to be homogeneous. Indentation tests are performed at different speeds and the force relaxation after a step indent is measured as well. White matter tissue is found to be stiffer than gray matter and to show more variation in response between different samples which is consistent with structural differences between white matter and gray matter. In addition to differences between white matter and gray matter, also different regions of brain tissue are compared.
U2 - 10.1016/j.jmbbm.2009.09.001
DO - 10.1016/j.jmbbm.2009.09.001
M3 - Article
C2 - 20129415
SN - 1751-6161
VL - 3
SP - 158
EP - 166
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
IS - 2
ER -