We consider manufacturing trade-offs for engineer-to-order proteins. The biomanufacturer needs to determine how much protein to produce, and then how much of it to waste in subsequent operations because of the purity and yield trade-offs. We develop a Markov decision model, and determine structural characteristics of the optimal operating policies.
Martagan, T. G., Krishnamurthy, A., & Leland, P. (2019). Managing trade-offs in protein manufacturing: how much to waste? Manufacturing & Service Operations Management, 22(2), 223-428. https://doi.org/10.1287/msom.2018.0740