Magnetically-actuated artificial cilia for microfluidic propulsion

S.N. Khaderi, C.B. Craus, J. Hussong, N. Schorr, J. Belardi, J. Westerweel, O. Prucker, J. Ruehe, J.M.J. Toonder, den, P.R. Onck

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

121 Citaten (Scopus)
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In this paper we quantitatively analyse the performance of magnetically-driven artificial cilia for labon-a-chip applications. The artificial cilia are fabricated using thin polymer films with embeddedmagnetic nano-particles and their deformation is studied under different external magnetic fields andflows. A coupled magneto-mechanical solidfluid model that accurately captures the interaction between the magnetic field, cilia and fluid is used to simulate the cilia motion. The elastic and magnetic properties of the cilia are obtained by fitting the results of the computational model to the experimental data. The performance of the artificial cilia with a non-uniform cross-section is characterised using the numerical model for two channel configurations that are of practical importance: an open-loop and a closed-loop channel. We predict that the flow and pressure head generated by the artificial cilia can be as high as 18 microlitres per minute and 3 mm of water, respectively. We also study the effect of metachronal waves on the flow generated and show that the fluid propelled increases drastically compared to synchronously beating cilia, and is unidirectional. This increase is significant even when the phase difference between adjacent cilia is small. The obtained results provide guidelines for the optimal design of magnetically-driven artificial cilia for microfluidic propulsion.
Originele taal-2Engels
Pagina's (van-tot)2002-2010
TijdschriftLab on a Chip
Nummer van het tijdschrift12
StatusGepubliceerd - 2011


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