Machine learning-derived active sleep as an early predictor of white matter development in preterm infants

Xiaowan Wang, Eline R. de Groot, Maria Luisa Tataranno, Anneloes L. van Baar, Femke Lammertink, Thomas Alderliesten, Xi Long, Manon J.N.L. Benders, Jeroen Dudink (Corresponding author)

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2 Citaten (Scopus)

Samenvatting

White matter dysmaturation is commonly seen in preterm infants admitted to the neonatal intensive care unit (NICU). Animal research has shown that active sleep is essential for early brain plasticity. This study aimed to determine the potential of active sleep as an early predictor for subsequent white matter development in preterm infants. Using heart and respiratory rates routinely monitored in the NICU, we developed a machine learning-based automated sleep stage classifier in a cohort of 25 preterm infants (12 females). The automated classifier was subsequently applied to a study cohort of 58 preterm infants (31 females) to extract active sleep percentage over 5-7 consecutive days during 29-32 weeks of postmenstrual age. Each of the 58 infants underwent high-quality T2-weighted magnetic resonance brain imaging at term-equivalent age, which was used to measure the total white matter volume. The association between active sleep percentage and white matter volume was examined using a multiple linear regression model adjusted for potential confounders. Using the automated classifier with a superior sleep classification performance [mean area under the receiver operating characteristic curve (AUROC) = 0.87, 95% CI 0.83-0.92], we found that a higher active sleep percentage during the preterm period was significantly associated with an increased white matter volume at term-equivalent age [ β  = 0.31, 95% CI 0.09-0.53, false discovery rate (FDR)-adjusted p-value = 0.021]. Our results extend the positive association between active sleep and early brain development found in animal research to human preterm infants and emphasize the potential benefit of sleep preservation in the NICU setting.

Originele taal-2Engels
Artikelnummere1024232023
TijdschriftJournal of Neuroscience
Volume44
Nummer van het tijdschrift5
DOI's
StatusGepubliceerd - 31 jan. 2024

Financiering

We thank Y.N. Jan and L.Y. Jan for providing Leica SP8 for high-resolution imaging during the pandemic. We acknowledge E. Ullian, M. Parades, M. Scanziani, J. Horton, M. Feller, and J. Hyer for their advice. We thank Y.M. Kuo, S.Y. Chang, J. Palpant, M. Lum, and E. Dang for their technical support. We acknowledge NEI P30EY002162 for University of California San Francisco Vision Core support, the funding from the RPB unrestricted fund, and the RPB-CDA Awards to UCSF-Ophthalmology; from Whitehall Foundation Award, GRF-CFC3, and National Institutes of Health (NIH; R01EY030138; R01NS123912) to X.D.; NIH (F30EY033201) to N.Y.T.; and NIH (T32NS115706) to A.C.M. The authors declare no competing financial interests. Correspondence should be addressed to Xin Duan at [email protected]. https://doi.org/10.1523/JNEUROSCI.1310-23.2023 Copyright © 2024 the authors

FinanciersFinanciernummer
National Institutes of Health, NIHF30EY033201, T32NS115706, R01NS123912, R01EY030138
National Eye InstituteP30EY002162
Whitehall FoundationGRF-CFC3
Research to Prevent Blindness

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