Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study

F.L. Heyer (Corresponding author), J.J.A. de Jong, P.C. Willems, J.J. Arts, S.G.P. Bours, S.M.J. van Kuijk, M. Poeze, P.P. Geusens, B. van Rietbergen, J.P. van den Bergh

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

Uittreksel

Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.

TaalEngels
Pagina's510-516
TijdschriftBone
Volume127
DOI's
StatusGepubliceerd - 1 okt 2019

Vingerafdruk

Radius Fractures
Bone Fractures
Wrist
Bone and Bones
Finite Element Analysis
Bone Density
Outcome Assessment (Health Care)
Clinical Trials
Pain
Surveys and Questionnaires

Citeer dit

Heyer, F. L., de Jong, J. J. A., Willems, P. C., Arts, J. J., Bours, S. G. P., van Kuijk, S. M. J., ... van den Bergh, J. P. (2019). Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study. Bone, 127, 510-516. DOI: 10.1016/j.bone.2019.06.013
Heyer, F.L. ; de Jong, J.J.A. ; Willems, P.C. ; Arts, J.J. ; Bours, S.G.P. ; van Kuijk, S.M.J. ; Poeze, M. ; Geusens, P.P. ; van Rietbergen, B. ; van den Bergh, J.P./ Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region : an HR-pQCT exploratory study. In: Bone. 2019 ; Vol. 127. blz. 510-516
@article{0b16d23b322548879e87a51f682f1628,
title = "Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study",
abstract = "Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.",
author = "F.L. Heyer and {de Jong}, J.J.A. and P.C. Willems and J.J. Arts and S.G.P. Bours and {van Kuijk}, S.M.J. and M. Poeze and P.P. Geusens and {van Rietbergen}, B. and {van den Bergh}, J.P.",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
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language = "English",
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Heyer, FL, de Jong, JJA, Willems, PC, Arts, JJ, Bours, SGP, van Kuijk, SMJ, Poeze, M, Geusens, PP, van Rietbergen, B & van den Bergh, JP 2019, 'Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study' Bone, vol. 127, blz. 510-516. DOI: 10.1016/j.bone.2019.06.013

Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region : an HR-pQCT exploratory study. / Heyer, F.L. (Corresponding author); de Jong, J.J.A.; Willems, P.C.; Arts, J.J.; Bours, S.G.P.; van Kuijk, S.M.J.; Poeze, M.; Geusens, P.P.; van Rietbergen, B.; van den Bergh, J.P.

In: Bone, Vol. 127, 01.10.2019, blz. 510-516.

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

TY - JOUR

T1 - Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region

T2 - Bone

AU - Heyer,F.L.

AU - de Jong,J.J.A.

AU - Willems,P.C.

AU - Arts,J.J.

AU - Bours,S.G.P.

AU - van Kuijk,S.M.J.

AU - Poeze,M.

AU - Geusens,P.P.

AU - van Rietbergen,B.

AU - van den Bergh,J.P.

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.

AB - Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.

U2 - 10.1016/j.bone.2019.06.013

DO - 10.1016/j.bone.2019.06.013

M3 - Article

VL - 127

SP - 510

EP - 516

JO - Bone

JF - Bone

SN - 8756-3282

ER -

Heyer FL, de Jong JJA, Willems PC, Arts JJ, Bours SGP, van Kuijk SMJ et al. Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study. Bone. 2019 okt 1;127:510-516. Beschikbaar vanaf, DOI: 10.1016/j.bone.2019.06.013