Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: an HR-pQCT exploratory study

F.L. Heyer (Corresponding author), J.J.A. de Jong, P.C. Willems, J.J. Arts, S.G.P. Bours, S.M.J. van Kuijk, M. Poeze, P.P. Geusens, B. van Rietbergen, J.P. van den Bergh

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review


Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (μFEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R2: 0.49, p = 0.006 and R2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with μFEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice.

Originele taal-2Engels
Pagina's (van-tot)510-516
Aantal pagina's7
StatusGepubliceerd - 1 okt 2019


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