Logic modeling in quantitative systems pharmacology

P. Traynard, L. Tobalina, F. Eduati, L. Calzone, J. Saez-Rodriguez (Corresponding author)

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

5 Citaties (Scopus)

Uittreksel

Here we present logic modeling as an approach to understand deregulation of signal transduction in disease and to characterize a drug's mode of action. We discuss how to build a logic model from the literature and experimental data and how to analyze the resulting model to obtain insights of relevance for systems pharmacology. Our workflow uses the free tools OmniPath (network reconstruction from the literature), CellNOpt (model fit to experimental data), MaBoSS (model analysis), and Cytoscape (visualization).

TaalEngels
Pagina's499-511
Aantal pagina's13
TijdschriftCPT: Pharmacometrics & Systems Pharmacology
Volume6
Nummer van het tijdschrift8
DOI's
StatusGepubliceerd - 1 aug 2017
Extern gepubliceerdJa

Vingerafdruk

Pharmacology
Logic
Workflow
Modeling
Experimental Data
Signal Transduction
Theoretical Models
Model Analysis
Signal transduction
Data Model
Work Flow
Deregulation
Drugs
Visualization
Model
Pharmaceutical Preparations

Trefwoorden

    Citeer dit

    Traynard, P., Tobalina, L., Eduati, F., Calzone, L., & Saez-Rodriguez, J. (2017). Logic modeling in quantitative systems pharmacology. CPT: Pharmacometrics & Systems Pharmacology, 6(8), 499-511. DOI: 10.1002/psp4.12225
    Traynard, P. ; Tobalina, L. ; Eduati, F. ; Calzone, L. ; Saez-Rodriguez, J./ Logic modeling in quantitative systems pharmacology. In: CPT: Pharmacometrics & Systems Pharmacology. 2017 ; Vol. 6, Nr. 8. blz. 499-511
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    Traynard, P, Tobalina, L, Eduati, F, Calzone, L & Saez-Rodriguez, J 2017, 'Logic modeling in quantitative systems pharmacology' CPT: Pharmacometrics & Systems Pharmacology, vol. 6, nr. 8, blz. 499-511. DOI: 10.1002/psp4.12225

    Logic modeling in quantitative systems pharmacology. / Traynard, P.; Tobalina, L.; Eduati, F.; Calzone, L.; Saez-Rodriguez, J. (Corresponding author).

    In: CPT: Pharmacometrics & Systems Pharmacology, Vol. 6, Nr. 8, 01.08.2017, blz. 499-511.

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

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    Traynard P, Tobalina L, Eduati F, Calzone L, Saez-Rodriguez J. Logic modeling in quantitative systems pharmacology. CPT: Pharmacometrics & Systems Pharmacology. 2017 aug 1;6(8):499-511. Beschikbaar vanaf, DOI: 10.1002/psp4.12225