TY - JOUR
T1 - Light-Responsive Elastin-Like Peptide-Based Targeted Nanoparticles for Enhanced Spheroid Penetration
AU - Le, Duc H.T.
AU - Ibrahimova, Vusala
AU - van den Wildenberg, Sebastian A.H.
AU - Wu, Hanglong
AU - Fonseca, Alba
AU - Torres, Tomas
AU - Garanger, Elisabeth
AU - Leenders, William P.J.
AU - Brock, Roland
AU - Lecommandoux, Sébastien
AU - van Hest, Jan C.M.
N1 - Funding Information:
This work was supported by EuroNanoMed3 TEMPEAT and SIRIC Brio Commucan projects. We also thank financial support to MINECO (PID2020-116490GB-I00, Porphyrinoids) and PCIN-2017-042, TEMPEAT), the Comunidad de Madrid (MAD2D-CM) and MICINN through project “Materiales disruptivos bidimensionales (2D)” within the Planes Complementarios (Materiales avanzados). The Nouvelle Aquitaine Region and the FRM are also thanked for financial support. IMDEA Nanociencia acknowledges support from the ‘‘Severo Ochoa’’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686).
Funding Information:
This work was supported by EuroNanoMed3 TEMPEAT and SIRIC Brio Commucan projects. We also thank financial support to MINECO (PID2020‐116490GB‐I00, Porphyrinoids) and PCIN‐2017‐042, TEMPEAT), the Comunidad de Madrid (MAD2D‐CM) and MICINN through project “Materiales disruptivos bidimensionales (2D)” within the Planes Complementarios (Materiales avanzados). The Nouvelle Aquitaine Region and the FRM are also thanked for financial support. IMDEA Nanociencia acknowledges support from the ‘‘Severo Ochoa’’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV‐2016‐0686).
Publisher Copyright:
© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
PY - 2023/6/12
Y1 - 2023/6/12
N2 - We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock ELP conjugates. Methionine residues in this monoblock are photo-oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π-π stacking, inducing the re-formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of “smart” nanomedicines with deeper penetration capacity for effective anticancer therapies.
AB - We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock ELP conjugates. Methionine residues in this monoblock are photo-oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π-π stacking, inducing the re-formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of “smart” nanomedicines with deeper penetration capacity for effective anticancer therapies.
KW - Elastin-Like Peptides
KW - Nanomedicine
KW - Photodynamic Therapy
KW - Self-Assembly
KW - Stimuli-Responsive
KW - Peptides/chemistry
KW - Micelles
KW - Nanoparticles/chemistry
KW - Elastin/chemistry
UR - http://www.scopus.com/inward/record.url?scp=85158098341&partnerID=8YFLogxK
U2 - 10.1002/anie.202300511
DO - 10.1002/anie.202300511
M3 - Article
C2 - 37083071
AN - SCOPUS:85158098341
SN - 1433-7851
VL - 62
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 24
M1 - e202300511
ER -
