Uittreksel
The rupture of a vulnerable carotid plaque featuring a lipid-rich necrotic core and intra-plaque haemorrhages is the major cause of stroke. Photoacoustic imaging (PAI) is a promising technique for assessing plaque vulnerability in the carotid artery due to its ability to assess the chemical composition in addition to its anatomy. However, assessment of chemical composition is usually based on the absorption differences of chromophores between multiple wavelengths, which heavily increase the complexity and cost of the imaging system. In this study, a new method based on single-wavelength PAI to detect intra-plaque haemorrhages, an important indicator of plaque vulnerability, is developed. The method uses wall filtering based on singular value decomposition. To test the method, a carotid plaque phantom mimicking intra-plaque haemorrhages, lumen and vasa vasorum is designed and imaged at 808nm in vitro. The phantom experiment shows wall filtering using singular value decomposition to be a viable method capable of discriminating signals originating from the lumen, vasa vasorum and intraplaque haemorrhages, allowing for the detection of intra-plaque haemorrhages with single wavelength PAI. This enables new opportunities for PAI of vulnerable carotid plaques with more cost effective and diverse laser sources.
| Originele taal-2 | Engels |
|---|---|
| Titel | Opto-Acoustic Methods and Applications in Biophotonics IV |
| Redacteuren | Vasilis Ntziachristos, Roger Zemp |
| Uitgeverij | SPIE |
| Aantal pagina's | 3 |
| ISBN van elektronische versie | 9781510628472 |
| ISBN van geprinte versie | 978-1-5106-2847-2 |
| DOI's | |
| Status | Gepubliceerd - 19 jul 2019 |
| Evenement | Opto-Acoustic Methods and Applications in Biophotonics IV 2019 - Munich, Duitsland Duur: 24 jun 2019 → 25 jun 2019 |
Publicatie series
| Naam | Proceedings of SPIE |
|---|---|
| Volume | 11077 |
Congres
| Congres | Opto-Acoustic Methods and Applications in Biophotonics IV 2019 |
|---|---|
| Land | Duitsland |
| Stad | Munich |
| Periode | 24/06/19 → 25/06/19 |
Vingerafdruk
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Intraplaque haemorrhage detection using single-wavelength PAI and singular value decomposition in the carotid artery. / van Hees, Roy P.M.; Wu, Min; van de Vosse, Frans N.; Lopata, Richard G.P.; Rutten, Marcel C.M.
Opto-Acoustic Methods and Applications in Biophotonics IV. redactie / Vasilis Ntziachristos; Roger Zemp. SPIE, 2019. 110771M (Proceedings of SPIE; Vol. 11077).Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review
TY - GEN
T1 - Intraplaque haemorrhage detection using single-wavelength PAI and singular value decomposition in the carotid artery
AU - van Hees, Roy P.M.
AU - Wu, Min
AU - van de Vosse, Frans N.
AU - Lopata, Richard G.P.
AU - Rutten, Marcel C.M.
PY - 2019/7/19
Y1 - 2019/7/19
N2 - The rupture of a vulnerable carotid plaque featuring a lipid-rich necrotic core and intra-plaque haemorrhages is the major cause of stroke. Photoacoustic imaging (PAI) is a promising technique for assessing plaque vulnerability in the carotid artery due to its ability to assess the chemical composition in addition to its anatomy. However, assessment of chemical composition is usually based on the absorption differences of chromophores between multiple wavelengths, which heavily increase the complexity and cost of the imaging system. In this study, a new method based on single-wavelength PAI to detect intra-plaque haemorrhages, an important indicator of plaque vulnerability, is developed. The method uses wall filtering based on singular value decomposition. To test the method, a carotid plaque phantom mimicking intra-plaque haemorrhages, lumen and vasa vasorum is designed and imaged at 808nm in vitro. The phantom experiment shows wall filtering using singular value decomposition to be a viable method capable of discriminating signals originating from the lumen, vasa vasorum and intraplaque haemorrhages, allowing for the detection of intra-plaque haemorrhages with single wavelength PAI. This enables new opportunities for PAI of vulnerable carotid plaques with more cost effective and diverse laser sources.
AB - The rupture of a vulnerable carotid plaque featuring a lipid-rich necrotic core and intra-plaque haemorrhages is the major cause of stroke. Photoacoustic imaging (PAI) is a promising technique for assessing plaque vulnerability in the carotid artery due to its ability to assess the chemical composition in addition to its anatomy. However, assessment of chemical composition is usually based on the absorption differences of chromophores between multiple wavelengths, which heavily increase the complexity and cost of the imaging system. In this study, a new method based on single-wavelength PAI to detect intra-plaque haemorrhages, an important indicator of plaque vulnerability, is developed. The method uses wall filtering based on singular value decomposition. To test the method, a carotid plaque phantom mimicking intra-plaque haemorrhages, lumen and vasa vasorum is designed and imaged at 808nm in vitro. The phantom experiment shows wall filtering using singular value decomposition to be a viable method capable of discriminating signals originating from the lumen, vasa vasorum and intraplaque haemorrhages, allowing for the detection of intra-plaque haemorrhages with single wavelength PAI. This enables new opportunities for PAI of vulnerable carotid plaques with more cost effective and diverse laser sources.
KW - CVENT
KW - Intraplaque haemorrhage
KW - Photoacoustic imaging
KW - Singular value decomposition
KW - intraplaque haemorrhage
KW - photoacoustic imaging
KW - singular value decomposition
UR - http://www.scopus.com/inward/record.url?scp=85074265019&partnerID=8YFLogxK
U2 - 10.1117/12.2527186
DO - 10.1117/12.2527186
M3 - Conference contribution
AN - SCOPUS:85074265019
SN - 978-1-5106-2847-2
T3 - Proceedings of SPIE
BT - Opto-Acoustic Methods and Applications in Biophotonics IV
A2 - Ntziachristos, Vasilis
A2 - Zemp, Roger
PB - SPIE
ER -