Integrating extracellular matrix-mimicking layers in microfluidic devices: More control over the tumor microenvironment

Hossein Eslami Amirabadi, Sheen SahebAli, Jean Philippe Frimat, Regina Luttge, Jaap M.J. den Toonder

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

Samenvatting

A challenge in studying cancer invasion is to understand the interaction between cancer cells and the extracellular matrix (ECM). Although the ECM influences cancer invasion, it is still unclear how its properties contribute to the process. Here, we present a new microfabrication method to integrate ECM-mimicking matrix layers between two microchannels. Using this chip, we have observed that the invasion distance of MDA-MB-231 breast cancer cells into 3D Polycaprolactone matrices and the general cell morphology are not affected by the ECM fiber diameter. The cells however produce longer and more protrusions in the matrix with smaller fiber size.

Originele taal-2Engels
Titel21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
UitgeverijChemical and Biological Microsystems Society
Pagina's1157-1158
Aantal pagina's2
ISBN van elektronische versie9780692941836
StatusGepubliceerd - 2017
Evenement21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah International Trade & Convention Center 1 International Drive Savannah, Georgia 31402 USA, Savannah, Verenigde Staten van Amerika
Duur: 22 okt 201726 okt 2017
Congresnummer: 21
http://www.microtasconferences.org/microtas2017/

Congres

Congres21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Verkorte titelMicroTAS 2017
Land/RegioVerenigde Staten van Amerika
StadSavannah
Periode22/10/1726/10/17
Internet adres

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