Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach

Joke Keijsers, Carole Leguy, Wouter Huberts, A.J. Narracott, J. Rittweger, Frans van de Vosse

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

62 Downloads (Pure)

Uittreksel

The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.
Originele taal-2Engels
Titel4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15)
RedacteurenP. Nithiarasu, E. Budyn
UitgeverijCMBE
Pagina's725-728
Aantal pagina's4
ISBN van elektronische versie978-0-9562914-3-1
StatusGepubliceerd - 2015
Evenement4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France - Ecole Normale Superieure de Cachan, Cachan, Frankrijk
Duur: 29 jun 20151 jul 2015
http://www.compbiomed.net/2015/

Publicatie series

NaamCMBE online proceedings series
Volume2015
ISSN van geprinte versie2227-3085
ISSN van elektronische versie2227-9385

Congres

Congres4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France
Verkorte titelCMBE 15
LandFrankrijk
StadCachan
Periode29/06/151/07/15
Ander4th International Conference Comutational & Mathematical Biomedical Engineering
Internet adres

Vingerafdruk

Muscle Contraction
Muscles
Muscle Relaxation
Baroreflex
Perfusion

Citeer dit

Keijsers, J., Leguy, C., Huberts, W., Narracott, A. J., Rittweger, J., & van de Vosse, F. (2015). Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach. In P. Nithiarasu, & E. Budyn (editors), 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15) (blz. 725-728). (CMBE online proceedings series; Vol. 2015). CMBE.
Keijsers, Joke ; Leguy, Carole ; Huberts, Wouter ; Narracott, A.J. ; Rittweger, J. ; van de Vosse, Frans. / Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach. 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15). redacteur / P. Nithiarasu ; E. Budyn. CMBE, 2015. blz. 725-728 (CMBE online proceedings series).
@inproceedings{b738bc1bc94c4bcaa7e2810221c00d48,
title = "Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach",
abstract = "The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.",
keywords = "muscle pump effect, arterial and venous 1D pulse wave propagation, local auto-regulation",
author = "Joke Keijsers and Carole Leguy and Wouter Huberts and A.J. Narracott and J. Rittweger and {van de Vosse}, Frans",
year = "2015",
language = "English",
series = "CMBE online proceedings series",
publisher = "CMBE",
pages = "725--728",
editor = "P. Nithiarasu and E. Budyn",
booktitle = "4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15)",

}

Keijsers, J, Leguy, C, Huberts, W, Narracott, AJ, Rittweger, J & van de Vosse, F 2015, Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach. in P Nithiarasu & E Budyn (redactie), 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15). CMBE online proceedings series, vol. 2015, CMBE, blz. 725-728, 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15), June 29-July 1, 2015, Cachan, France, Cachan, Frankrijk, 29/06/15.

Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach. / Keijsers, Joke; Leguy, Carole; Huberts, Wouter; Narracott, A.J.; Rittweger, J.; van de Vosse, Frans.

4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15). redactie / P. Nithiarasu; E. Budyn. CMBE, 2015. blz. 725-728 (CMBE online proceedings series; Vol. 2015).

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

TY - GEN

T1 - Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach

AU - Keijsers, Joke

AU - Leguy, Carole

AU - Huberts, Wouter

AU - Narracott, A.J.

AU - Rittweger, J.

AU - van de Vosse, Frans

PY - 2015

Y1 - 2015

N2 - The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.

AB - The muscle pump effect increases venous return during muscle contraction and perfusion during muscle relaxation. To investigate the additional contribution of different local auto-regulation mechanisms, a 1D pulse wave propagation model representing the calf vasculature is combined with a local auto-regulation model, which accounts for the metabolic, myogenic and endothelial regulation mechanisms. A simulated muscle contraction results in an increased arterial flow, as observed in literature. However, the expected decrease in baseline flow in the upright position is smaller than observed in vivo. In future research, other physiological mechanisms, such as the baroreflex, will be included.

KW - muscle pump effect

KW - arterial and venous 1D pulse wave propagation

KW - local auto-regulation

M3 - Conference contribution

T3 - CMBE online proceedings series

SP - 725

EP - 728

BT - 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15)

A2 - Nithiarasu, P.

A2 - Budyn, E.

PB - CMBE

ER -

Keijsers J, Leguy C, Huberts W, Narracott AJ, Rittweger J, van de Vosse F. Influence of local auto-regulation mechanisms on flow during the muscle pump effect: a modeling approach. In Nithiarasu P, Budyn E, redacteurs, 4th International Conference on Computational & Mathematical Biomedical Engineering (CMBE15). CMBE. 2015. blz. 725-728. (CMBE online proceedings series).