Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy

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Samenvatting

A photocrosslinkable protein G variant was used as an adapter protein to covalently and site-specifically conjugate an antibody and an Fc-fusion protein to an oligonucleotide. This modular approach enables straightforward decoration of DNA nanostructures with complex native proteins, allowing precise control over the nanoscale spatial organization of such proteins for in vitro and in vivo biomedical applications.
Originele taal-2Engels
Pagina's (van-tot)7393-7396
Aantal pagina's4
TijdschriftChemical Communications
Volume53
Nummer van het tijdschrift53
DOI's
StatusGepubliceerd - 7 jul 2017

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