Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology

Carole A.D. Leguy, J.M.T. Keijsers, W. Huberts, A.J. Narracott, J. Rittweger, F.N. van de Vosse

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Human factors remain an important issue for long term space flight. In particular, a better understanding of the response of the cardiovascular system to changes in orthostatic stress is crucial for the development of better countermeasures for astronauts. The goal of this study is to better characterize blood fluid shift during orthostatic stress using 1D pulse propagation model that will includes the effects of gravity on the arterial and venous system. Effects of gravity and vein collapsible properties were implemented in a 1D pulse wave propagation model. For single artery/vein model, we have shown that the model is able to simulate hydrostatic pressure and qualitatively reproduce increased arterial blood volume flow after a muscle contraction that is an influential phenomenon in orthostatic tolerance via increased venous return. To go forwards to a qualitative estimate of in vivo data, a model of the full circulation has to be considered and peripheral vascular regulation has to be implemented. We aim at a better represention of physiological responses and provide new information about the relative importance of the different phenomena involved in fluid shift towards the lower body.
Originele taal-2Engels
Titel3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013
RedacteurenP. Nithiarasu, R. Loehner
UitgeverijCMBE
Pagina's397-400
Aantal pagina's4
StatusGepubliceerd - 2013
Evenement3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13) - City University of Hong Kong, Hong Kong, China
Duur: 16 dec 201318 dec 2013
http://www.compbiomed.net/2013/

Publicatie series

NaamCMBE online proceedings series
Volume2013
ISSN van geprinte versie2227-3085
ISSN van elektronische versie2227-9385

Congres

Congres3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13)
Verkorte titelCMBE13
LandChina
StadHong Kong
Periode16/12/1318/12/13
AnderInternational Conference on Computational and Mathematical Biomedical Engineering
Internet adres

Vingerafdruk

Blood pressure
Physiology
Wave propagation
Gravitation
Blood
Cardiovascular system
Fluids
Hydrostatic pressure
Space flight
Human engineering
Muscle

Citeer dit

Leguy, C. A. D., Keijsers, J. M. T., Huberts, W., Narracott, A. J., Rittweger, J., & van de Vosse, F. N. (2013). Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology. In P. Nithiarasu, & R. Loehner (editors), 3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013 (blz. 397-400). (CMBE online proceedings series; Vol. 2013). CMBE.
Leguy, Carole A.D. ; Keijsers, J.M.T. ; Huberts, W. ; Narracott, A.J. ; Rittweger, J. ; van de Vosse, F.N. / Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology. 3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013. redacteur / P. Nithiarasu ; R. Loehner. CMBE, 2013. blz. 397-400 (CMBE online proceedings series).
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title = "Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology",
abstract = "Human factors remain an important issue for long term space flight. In particular, a better understanding of the response of the cardiovascular system to changes in orthostatic stress is crucial for the development of better countermeasures for astronauts. The goal of this study is to better characterize blood fluid shift during orthostatic stress using 1D pulse propagation model that will includes the effects of gravity on the arterial and venous system. Effects of gravity and vein collapsible properties were implemented in a 1D pulse wave propagation model. For single artery/vein model, we have shown that the model is able to simulate hydrostatic pressure and qualitatively reproduce increased arterial blood volume flow after a muscle contraction that is an influential phenomenon in orthostatic tolerance via increased venous return. To go forwards to a qualitative estimate of in vivo data, a model of the full circulation has to be considered and peripheral vascular regulation has to be implemented. We aim at a better represention of physiological responses and provide new information about the relative importance of the different phenomena involved in fluid shift towards the lower body.",
keywords = "wave propagation model, venous system, hydrostatic pressure, muscle pump",
author = "Leguy, {Carole A.D.} and J.M.T. Keijsers and W. Huberts and A.J. Narracott and J. Rittweger and {van de Vosse}, F.N.",
year = "2013",
language = "English",
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Leguy, CAD, Keijsers, JMT, Huberts, W, Narracott, AJ, Rittweger, J & van de Vosse, FN 2013, Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology. in P Nithiarasu & R Loehner (redactie), 3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013. CMBE online proceedings series, vol. 2013, CMBE, blz. 397-400, 3rd International Conference on Computational & Mathematical Biomedical Engineering (CMBE13), Hong Kong, China, 16/12/13.

Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology. / Leguy, Carole A.D.; Keijsers, J.M.T.; Huberts, W.; Narracott, A.J.; Rittweger, J.; van de Vosse, F.N.

3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013. redactie / P. Nithiarasu; R. Loehner. CMBE, 2013. blz. 397-400 (CMBE online proceedings series; Vol. 2013).

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

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AU - Leguy, Carole A.D.

AU - Keijsers, J.M.T.

AU - Huberts, W.

AU - Narracott, A.J.

AU - Rittweger, J.

AU - van de Vosse, F.N.

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N2 - Human factors remain an important issue for long term space flight. In particular, a better understanding of the response of the cardiovascular system to changes in orthostatic stress is crucial for the development of better countermeasures for astronauts. The goal of this study is to better characterize blood fluid shift during orthostatic stress using 1D pulse propagation model that will includes the effects of gravity on the arterial and venous system. Effects of gravity and vein collapsible properties were implemented in a 1D pulse wave propagation model. For single artery/vein model, we have shown that the model is able to simulate hydrostatic pressure and qualitatively reproduce increased arterial blood volume flow after a muscle contraction that is an influential phenomenon in orthostatic tolerance via increased venous return. To go forwards to a qualitative estimate of in vivo data, a model of the full circulation has to be considered and peripheral vascular regulation has to be implemented. We aim at a better represention of physiological responses and provide new information about the relative importance of the different phenomena involved in fluid shift towards the lower body.

AB - Human factors remain an important issue for long term space flight. In particular, a better understanding of the response of the cardiovascular system to changes in orthostatic stress is crucial for the development of better countermeasures for astronauts. The goal of this study is to better characterize blood fluid shift during orthostatic stress using 1D pulse propagation model that will includes the effects of gravity on the arterial and venous system. Effects of gravity and vein collapsible properties were implemented in a 1D pulse wave propagation model. For single artery/vein model, we have shown that the model is able to simulate hydrostatic pressure and qualitatively reproduce increased arterial blood volume flow after a muscle contraction that is an influential phenomenon in orthostatic tolerance via increased venous return. To go forwards to a qualitative estimate of in vivo data, a model of the full circulation has to be considered and peripheral vascular regulation has to be implemented. We aim at a better represention of physiological responses and provide new information about the relative importance of the different phenomena involved in fluid shift towards the lower body.

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Leguy CAD, Keijsers JMT, Huberts W, Narracott AJ, Rittweger J, van de Vosse FN. Including gravitational stress in a blood pressure wave propagation model for cardiovascular space physiology. In Nithiarasu P, Loehner R, redacteurs, 3rd International Conference on Computational and Mathematical Biomedical Engineering - CMBE2013, 16-18 December 2013. CMBE. 2013. blz. 397-400. (CMBE online proceedings series).