TY - JOUR
T1 - In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia
AU - Indermun, S.
AU - Choonara, Y.E.
AU - Kumar, P.
AU - du Toit, L.C.
AU - Modi, G.
AU - Luttge, R.
AU - Govender, M.
AU - Pillay, V.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
AB - With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
KW - Hydrogels
KW - IVIVC
KW - Pharmacokinetics
KW - Responsive drug delivery
KW - Skin
KW - Transdermal drug delivery
KW - responsive drug delivery
KW - transdermal drug delivery
KW - pharmacokinetics
KW - skin
KW - Hydrogel, Polyethylene Glycol Dimethacrylate/administration & dosage
KW - Electric Stimulation/methods
KW - Rats
KW - Microinjections/methods
KW - Administration, Cutaneous
KW - Rats, Sprague-Dawley
KW - Skin Absorption/drug effects
KW - Animals
KW - Drug Delivery Systems/methods
KW - Analgesia/methods
UR - http://www.scopus.com/inward/record.url?scp=85010973253&partnerID=8YFLogxK
U2 - 10.1016/j.xphs.2016.12.022
DO - 10.1016/j.xphs.2016.12.022
M3 - Article
C2 - 28057546
AN - SCOPUS:85010973253
VL - 106
SP - 1111
EP - 1116
JO - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
SN - 0928-0987
IS - 4
ER -