Uittreksel
With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
| Taal | Engels |
|---|---|
| Pagina's | 1111–1116 |
| Aantal pagina's | 6 |
| Tijdschrift | European Journal of Pharmaceutical Sciences |
| Volume | 106 |
| Nummer van het tijdschrift | 4 |
| DOI's | |
| Status | Gepubliceerd - 2017 |
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In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia. / Indermun, S.; Choonara, Y.E.; Kumar, P.; du Toit, L.C.; Modi, G.; Luttge, R.; Govender, M.; Pillay, V.
In: European Journal of Pharmaceutical Sciences, Vol. 106, Nr. 4, 2017, blz. 1111–1116.Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review
TY - JOUR
T1 - In Vitro and In Vivo evaluation of a hydrogel-based microneedle device for transdermal electro-modulated analgesia
AU - Indermun,S.
AU - Choonara,Y.E.
AU - Kumar,P.
AU - du Toit,L.C.
AU - Modi,G.
AU - Luttge,R.
AU - Govender,M.
AU - Pillay,V.
PY - 2017
Y1 - 2017
N2 - With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
AB - With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This article details the in vitro and in vivo evaluation of a transdermal electro-modulated hydrogel-microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the electro-modulated hydrogel was undertaken before the determination of the in vivo release, histopathologic and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model. Pharmacokinetic modeling was conducted to establish a level A in vitro-in vivo correlation. Data analysis was carried out by segmenting the combined in vivo release profile into individualistic profiles before analysis.
KW - Hydrogels
KW - IVIVC
KW - Pharmacokinetics
KW - Responsive drug delivery
KW - Skin
KW - Transdermal drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85010973253&partnerID=8YFLogxK
U2 - 10.1016/j.xphs.2016.12.022
DO - 10.1016/j.xphs.2016.12.022
M3 - Article
VL - 106
SP - 1111
EP - 1116
JO - European Journal of Pharmaceutical Sciences
T2 - European Journal of Pharmaceutical Sciences
JF - European Journal of Pharmaceutical Sciences
SN - 0928-0987
IS - 4
ER -