In silico modelling and analysis of ribosome kinetics and aa-tRNA competition

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademic

2 Citaten (Scopus)

Samenvatting

We present a formal analysis of ribosome kinetics using probabilistic model checking and the tool Prism. We compute different parameters of the model, like probabilities of translation errors and average insertion times per codon. The model predicts strong correlation to the quotient of the concentrations of the so-called cognate and near-cognate tRNAs, in accord with experimental findings and other studies. Using piecewise analysis of the model, we are able to give an analytical explanation of this observation.
Originele taal-2Engels
TitelTransactions on Computational Systems Biology XI
RedacteurenC. Priami, R.J. Back, I. Petre
Plaats van productieBerlin
UitgeverijSpringer
Pagina's69-89
ISBN van geprinte versie978-3-642-04185-3
DOI's
StatusGepubliceerd - 2009

Publicatie series

NaamLecture notes in computer science
Volume5750

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  • Citeer dit

    Bosnacki, D., Pronk, T. E., & Vink, de, E. P. (2009). In silico modelling and analysis of ribosome kinetics and aa-tRNA competition. In C. Priami, R. J. Back, & I. Petre (editors), Transactions on Computational Systems Biology XI (blz. 69-89). (Lecture notes in computer science; Vol. 5750). Springer. https://doi.org/10.1007/978-3-642-04186-0_4