Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: A multimodality investigation

Matti M. Van Schooneveld, Esad Vucic, Rolf Koole, Yu Zhou, Joanne Stocks, David P. Cormode, Cheuk Y. Tang, Ronald E. Gordon, Klaas Nicolay, Andries Meijerink, Zahi A. Fayad, Willem J.M. Mulder

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

188 Citaten (Scopus)

Samenvatting

Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.

Originele taal-2Engels
Pagina's (van-tot)2517-2525
Aantal pagina's9
TijdschriftNano Letters
Volume8
Nummer van het tijdschrift8
DOI's
StatusGepubliceerd - aug 2008

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