Implementation and validation of a 2D-3D rigid registration algorithm for proton gantry and stereotactic radiosurgery systems

M. Zhu, G.J.J. Warmerdam, P. Steininger, M. Neuner, G. Sharp, H. Shih, B. Winey

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademic

Samenvatting

Purpose: To implement and validate the accuracy of an intensity-based 2D to 3D rigid registration algorithm for proton treatment systems. Methods: A 2D-3D rigid registration algorithm (REG23) was previously validated for linac machines. We adapted REG23 for use in both gantry-based and Stereotactic Alignment in Radiosurgery (STAR) proton treatment systems. REG23 registration was run on NVIDIA Quadra600 GPU card using NCC metrics and AMOEBA optimizer and validated using dual orthogonal kV images acquired during cranial target treatments: 66 fractions to 7 patients in gantry system and 135 fractions to 9 patients in STAR. Rectangle ROIs covering the whole region superior to the base-of-skull were used for REG23 registration and the accuracy was evaluated using clinical utilized fiducial-based 2D-3D ray back-projection rigid registration as the baseline. Results: For the gantry system, the differences between REG23 and baseline were -0.01±0.63 mm, 0.43±0.61 mm, 0.12±0.60 mm in the left-right, superior-inferior, and anterior-posterior directions; 0.15±0.44°, 0.11±0.23°, and 0.19±0.37° in pitch, roll, and yaw, respectively. The vector difference was 1.04±0.48 mm. For STAR system, the REG23 results were -0.34±0.45 mm, -0.10±0.36 mm, -0.38±0.75 mm, -0.14±0.54°, 0.04±0.18°, and 0.03±0.35° different than the baseline in the left-right, superior-inferior, and anterior-posterior directions, pitch, roll, and yaw. The vector difference was 0.93±0.53 mm. The time for REG23 automatic registration was 29.7±9.5 seconds. Conclusion: We demonstrated that the intensity based 2D-3D rigid registration algorithm REG23 provided sub-millimeter accuracy and better than 0.5° for both gantry-based and STAR proton treatment systems for cranial patients. This accuracy is within patient setup tolerance for current fractionated proton treatment systems. Given its accuracy and efficiency, we believe REG23 has great potential for clinical utilization in proton radiation therapy by replacing the implanted fiducial or anatomic feature based patient setup method.
Originele taal-2Engels
TitelAAPM 2013 proceedings of the 55th annual meeting and exhibiton, 4-8 August 2013, Indianapolis
DOI's
StatusGepubliceerd - 2013
Evenementconference; American Association of Physicists in Medicine; 2013-08-04; 2013-08-08 -
Duur: 4 aug 20138 aug 2013

Publicatie series

NaamMedical Physics
Nummer6
Volume40
ISSN van geprinte versie0094-2405

Congres

Congresconference; American Association of Physicists in Medicine; 2013-08-04; 2013-08-08
Periode4/08/138/08/13
AnderAmerican Association of Physicists in Medicine

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