Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazo[5,1-c] [1,4] oxazines

E.F. Godefroi; C.A.M. Van der Eycken; P.A.J. Janssen

doi:10.1021/jo01341a037

Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazo[5,1-c] [1,4] oxazines

E.F. Godefroi, C.A.M. Van der Eycken, P.A.J. Janssen

Chemical Engineering and Chemistry

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

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Samenvatting

cf. 62, 10428d. The synthesis of DL-1-(a-carboxybenzyl)imidazole-5-carboxylic acid is described. This compd. reacts with acetic and propionic anhydride to give enol lactones Ia and b, resp. Redn. of the corresponding oxo acids IIa and b with sodium borohydride, gives, upon heating, lactones IIIa and b.

Originele taal-2	Engels
Pagina's (van-tot)	806-808
Aantal pagina's	3
Tijdschrift	Journal of Organic Chemistry
Volume	31
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1021/jo01341a037
Status	Gepubliceerd - 1966

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10.1021/jo01341a037

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Citeer dit

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title = "Imidazoles as hypnotic agents. II. The synthesis of certain 5,6-disubstituted 8-oxo-8H-imidazo[5,1-c] [1,4] oxazines",

abstract = "cf. 62, 10428d. The synthesis of DL-1-(a-carboxybenzyl)imidazole-5-carboxylic acid is described. This compd. reacts with acetic and propionic anhydride to give enol lactones Ia and b, resp. Redn. of the corresponding oxo acids IIa and b with sodium borohydride, gives, upon heating, lactones IIIa and b.",

author = "E.F. Godefroi and {Van der Eycken}, C.A.M. and P.A.J. Janssen",

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AU - Godefroi, E.F.

AU - Van der Eycken, C.A.M.

AU - Janssen, P.A.J.

PY - 1966

Y1 - 1966

N2 - cf. 62, 10428d. The synthesis of DL-1-(a-carboxybenzyl)imidazole-5-carboxylic acid is described. This compd. reacts with acetic and propionic anhydride to give enol lactones Ia and b, resp. Redn. of the corresponding oxo acids IIa and b with sodium borohydride, gives, upon heating, lactones IIIa and b.

AB - cf. 62, 10428d. The synthesis of DL-1-(a-carboxybenzyl)imidazole-5-carboxylic acid is described. This compd. reacts with acetic and propionic anhydride to give enol lactones Ia and b, resp. Redn. of the corresponding oxo acids IIa and b with sodium borohydride, gives, upon heating, lactones IIIa and b.

U2 - 10.1021/jo01341a037

DO - 10.1021/jo01341a037

M3 - Article

VL - 31

SP - 806

EP - 808

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 3

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