Identification of a switching model of calcium cycling in isolated rat hearts

J. Op den Buijs, A.L. Juloski, T. Ivanics, L. Ligeti, G.J. Vusse, van der, N.A.W. Riel, van

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureConferentiebijdrageAcademicpeer review

2 Citaten (Scopus)

Samenvatting

So far, the processes involved in regulation of intracellular calcium (Ca/sub i//sup 2+/) in cardiomyocytes have been mainly studied through biochemical and isolated cell analysis. Here, we present a novel technique to model and identify cardiac Ca/sub i//sup 2+/-cycling under physiologically relevant conditions in the intact beating heart. Ca/sub i//sup 2+/ was measured using fluorescence techniques in ex vivo perfused rat hearts. For analysis, we developed a parametric mathematical model, switching between active and inactive calcium release. The kinetic parameters of the two submodes of the model were computed using a recently developed technique from hybrid system identification. Application of the method to control and isoproterenol-stimulated hearts resulted in parameter values within a physiologically reliable range.
Originele taal-2Engels
TitelEMBC : Engineering in medicine and biology : annual international conference : proceedings, 26th, September 1-5, 2004
Plaats van productiePiscataway, NJ, USA
UitgeverijInstitute of Electrical and Electronics Engineers
Pagina's841-844
ISBN van geprinte versie0-7803-8439-3
DOI's
StatusGepubliceerd - 2004
Evenement26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, Verenigde Staten van Amerika
Duur: 1 sep. 20045 sep. 2004
Congresnummer: 26

Congres

Congres26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
Verkorte titelEMBC 2004
Land/RegioVerenigde Staten van Amerika
StadSan Francisco
Periode1/09/045/09/04
Ander26th Conference IEEE Engineering in Medicine and Biology

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