TY - JOUR
T1 - Hypothermia for Reduction of Myocardial Reperfusion Injury in Acute Myocardial Infarction
T2 - Closing the Translational Gap
AU - El Farissi, Mohamed
AU - Keulards, Danielle C.J.
AU - Zelis, Jo M.
AU - van 't Veer, Marcel
AU - Zimmermann, Frederik M.
AU - Pijls, Nico H.J.
AU - Otterspoor, Luuk C.
N1 - Publisher Copyright:
© 2021 Georg Thieme Verlag. All rights reserved.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Myocardial reperfusion injury - triggered by an inevitable inflammatory response after reperfusion - may undo a considerable part of the myocardial salvage achieved through timely percutaneous coronary intervention in patients with acute myocardial infarction. Because infarct size is strongly correlated to mortality and risk of heart failure, the importance of endeavors for cardioprotective therapies to attenuate myocardial reperfusion injury and decrease infarct size remains undisputed. Myocardial reperfusion injury is the result of several complex nonlinear phenomena, and for a therapy to be effective, it should act on multiple targets involved in this injury. In this regard, hypothermia remains a promising treatment despite a number of negative randomized controlled trials in humans with acute myocardial infarction so far. To turn the tide for hypothermia in patients with acute myocardial infarction, sophisticated solutions for important limitations of systemic hypothermia should continue to be developed. In this review, we provide a comprehensive overview of the pathophysiology and clinical expression of myocardial reperfusion injury and discuss the current status and possible future of hypothermia for cardioprotection in patients with acute myocardial infarction.
AB - Myocardial reperfusion injury - triggered by an inevitable inflammatory response after reperfusion - may undo a considerable part of the myocardial salvage achieved through timely percutaneous coronary intervention in patients with acute myocardial infarction. Because infarct size is strongly correlated to mortality and risk of heart failure, the importance of endeavors for cardioprotective therapies to attenuate myocardial reperfusion injury and decrease infarct size remains undisputed. Myocardial reperfusion injury is the result of several complex nonlinear phenomena, and for a therapy to be effective, it should act on multiple targets involved in this injury. In this regard, hypothermia remains a promising treatment despite a number of negative randomized controlled trials in humans with acute myocardial infarction so far. To turn the tide for hypothermia in patients with acute myocardial infarction, sophisticated solutions for important limitations of systemic hypothermia should continue to be developed. In this review, we provide a comprehensive overview of the pathophysiology and clinical expression of myocardial reperfusion injury and discuss the current status and possible future of hypothermia for cardioprotection in patients with acute myocardial infarction.
KW - hypothermia
KW - myocardial infarction
KW - percutaneous coronary intervention
KW - reperfusion
KW - Percutaneous Coronary Intervention/adverse effects
KW - Myocardial Reperfusion Injury/etiology
KW - Humans
KW - Myocardial Infarction/therapy
KW - Hypothermia
KW - Hypothermia, Induced/adverse effects
KW - Myocardial Reperfusion/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=85113814559&partnerID=8YFLogxK
U2 - 10.1161/CIRCINTERVENTIONS.120.010326
DO - 10.1161/CIRCINTERVENTIONS.120.010326
M3 - Review article
C2 - 34266310
AN - SCOPUS:85113814559
SN - 1941-7640
VL - 14
JO - Circulation: Cardiovascular Interventions
JF - Circulation: Cardiovascular Interventions
IS - 8
M1 - e010326
ER -