Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone

A.E. Tami, M.M. Leitner, M.G. Baucke, T.L. Mueller, G.H. Lenthe, van, R. Müller, K. Ito

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Samenvatting

In osteoporotic bones, resorption exceeds formation during the remodelling phase of bone turnover. As a consequence, decreased bone volume and bone contact result in the peri-implant region. This may subsequently lead to loss of fixation. In this study we investigated whether the presence of nonresorbable, osteoconductive hydroxyapatite (HA) particles could help maintain a denser and more functional peri-implant bone structure. Titanium screws were implanted into the proximal tibial metaphysis of four months old, ovariectomized Wistar rats (n = 60). In the right tibia, the drill hole was first filled with HA particles, while the left tibia served as a control without HA particles. Histological analysis demonstrated that during the remodelling phase the amount of newly formed bone was significantly higher on the HA over the control side. Micro-CT analysis corroborated the significant changes over time as well as differences in peri-implant bone volume density between treatment and control group. Mechanical tests demonstrated that the pull-out force was greater with HA particles. These results indicate that HA particles are able to induce and maintain for a longer time a denser peri-implant bone mantle in osteoporotic bone, which may have important implications in the prevention of implant migration and cut-outs. © 2009 Elsevier Inc. All rights reserved.
Originele taal-2Engels
Pagina's (van-tot)1117-1124
TijdschriftBone
Volume45
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 2009

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