Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen; L. Albertazzi; A.P.H.J. Schenning; L.-G. Milroy; L. Brunsveld

doi:10.1039/c6cc08793k

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A.H.A.M. van Onzen
, L. Albertazzi
, A.P.H.J. Schenning
, L.-G. Milroy
, L. Brunsveld (Corresponding author)

Chemical Biology

Onderzoeksoutput: Bijdrage aan tijdschrift › Tijdschriftartikel › Academic › peer review

7 Citaten (Scopus)

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The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

Originele taal-2	Engels
Pagina's (van-tot)	1626-1629
Aantal pagina's	4
Tijdschrift	Chemical Communications, ChemComm
Volume	53
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1039/c6cc08793k
Status	Gepubliceerd - 4 feb. 2017

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10.1039/c6cc08793k

publisher versionDefinitieve gepubliceerde versie, 2,52 MBLicentie: CC BY-NC

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abstract = "The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.",

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AU - Albertazzi, L.

AU - Schenning, A.P.H.J.

AU - Milroy, L.-G.

AU - Brunsveld, L.

PY - 2017/2/4

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AB - The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

KW - Cytosol/chemistry

KW - Fluorescent Dyes/chemical synthesis

KW - HeLa Cells

KW - Humans

KW - Hydrophobic and Hydrophilic Interactions

KW - Nanoparticles/chemistry

KW - Spectrometry, Fluorescence

UR - https://www.scopus.com/pages/publications/85010977548

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Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

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