Samenvatting
Objective: Physical activity may provide a means for the prevention of cardiovascular disease via improving microvascular function. Therefore, this study investigated whether physical activity is associated with skin and retinal microvascular function. Methods: In The Maastricht Study, a population-based cohort study enriched with type 2 diabetes (n = 1298, 47.3% women, aged 60.2 ± 8.1 years, 29.5% type 2 diabetes), we studied whether accelerometer-assessed physical activity and sedentary time associate with skin and retinal microvascular function. Associations were studied by linear regression and adjusted for major cardiovascular risk factors. In addition, we investigated whether associations were stronger in type 2 diabetes. Results: In individuals with type 2 diabetes, total physical activity and higher-intensity physical activity were independently associated with greater heat-induced skin hyperemia (regression coefficients per hour), respectively, 10 (95% CI: 1; 18) and 36 perfusion units (14; 58). In individuals without type 2 diabetes, total physical activity and higher-intensity physical activity were not associated with heat-induced skin hyperemia. No associations with retinal arteriolar %-dilation were identified. Conclusion: Higher levels of total and higher-intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without, type 2 diabetes.
Originele taal-2 | Engels |
---|---|
Artikelnummer | e12611 |
Tijdschrift | Microcirculation |
Volume | 27 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Gepubliceerd - 1 mei 2020 |
Financiering
This study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), CARIM School for Cardiovascular Diseases (Maastricht, the Netherlands), CAPHRI School for Public Health and Primary Care (Maastricht, the Netherlands), NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands), Perimed (J?rf?lla, Sweden), Diabetesfonds (Amersfoort, The Netherlands) (grant 2016.22.1878), and Oogfonds (Utrecht, The Netherlands) and by unrestricted grants from Janssen-Cilag BV (Tilburg, the Netherlands), Novo Nordisk Farma BV (Alphen aan den Rijn, the Netherlands), and Sanofi-Aventis Netherlands BV (Gouda, the Netherlands). The authors would like to acknowledge ZIO foundation (Vereniging Regionale HuisartsenZorg Heuvelland) for their contribution to The Maastricht Study. The researchers are indebted to the participants for their willingness to participate in the study.
Financiers | Financiernummer |
---|---|
Medical College of Winconsin | |
Ministerie van Economische Zaken en Klimaat | 31O.041 |
European Regional Development Fund | |
Maastricht University Medical Center |