High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat; Marc Hulsman; Kamiel Cornelissen; Bernke Papenburg; Roman K. Truckenmüller; Gerhard F. Post; Marc Uetz; Marcel J.T. Reinders; Dimitrios Stamatialis; Clemens Van Blitterswijk; Jan De Boer

High-throughput screening of cell-surface topographic interactions

Hemant V. Unadkat, Marc Hulsman, Kamiel Cornelissen, Bernke Papenburg, Roman K. Truckenmüller, Gerhard F. Post, Marc Uetz, Marcel J.T. Reinders, Dimitrios Stamatialis, Clemens Van Blitterswijk, Jan De Boer

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

Samenvatting

High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

Originele taal-2	Engels
Titel	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pagina's	2083-2084
Aantal pagina's	2
Status	Gepubliceerd - 1 dec 2010
Extern gepubliceerd	Ja
Evenement	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Nederland Duur: 3 okt 2010 → 7 okt 2010 Congresnummer: 14 http://www.microtasconferences.org/microtas2010/

Publicatie series

Naam	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume	3

Congres

Congres	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Verkorte titel	MicroTAS 2010
Land	Nederland
Stad	Groningen
Periode	3/10/10 → 7/10/10
Ander	14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, the Netherlands
Internet adres	http://www.microtasconferences.org/microtas2010/

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Unadkat, H. V., Hulsman, M., Cornelissen, K., Papenburg, B., Truckenmüller, R. K., Post, G. F., Uetz, M., Reinders, M. J. T., Stamatialis, D., Van Blitterswijk, C., & De Boer, J. (2010). High-throughput screening of cell-surface topographic interactions. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (blz. 2083-2084). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).

Unadkat, Hemant V. ; Hulsman, Marc ; Cornelissen, Kamiel ; Papenburg, Bernke ; Truckenmüller, Roman K. ; Post, Gerhard F. ; Uetz, Marc ; Reinders, Marcel J.T. ; Stamatialis, Dimitrios ; Van Blitterswijk, Clemens ; De Boer, Jan. / High-throughput screening of cell-surface topographic interactions. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. blz. 2083-2084 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).

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title = "High-throughput screening of cell-surface topographic interactions",

abstract = "High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.",

keywords = "Biomaterials, Cell behavior, High-throughput screening, Micro-nanotopographies",

author = "Unadkat, {Hemant V.} and Marc Hulsman and Kamiel Cornelissen and Bernke Papenburg and Truckenm{\"u}ller, {Roman K.} and Post, {Gerhard F.} and Marc Uetz and Reinders, {Marcel J.T.} and Dimitrios Stamatialis and {Van Blitterswijk}, Clemens and {De Boer}, Jan",

year = "2010",

month = dec,

day = "1",

language = "English",

isbn = "9781618390622",

series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

pages = "2083--2084",

booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",

note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",

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Unadkat, HV, Hulsman, M, Cornelissen, K, Papenburg, B, Truckenmüller, RK, Post, GF, Uetz, M, Reinders, MJT, Stamatialis, D, Van Blitterswijk, C & De Boer, J 2010, High-throughput screening of cell-surface topographic interactions. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, vol. 3, blz. 2083-2084, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Nederland, 3/10/10.

High-throughput screening of cell-surface topographic interactions. / Unadkat, Hemant V.; Hulsman, Marc; Cornelissen, Kamiel; Papenburg, Bernke; Truckenmüller, Roman K.; Post, Gerhard F.; Uetz, Marc; Reinders, Marcel J.T.; Stamatialis, Dimitrios; Van Blitterswijk, Clemens; De Boer, Jan.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. blz. 2083-2084 (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 3).

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/Congresprocedure › Conferentiebijdrage › Academic › peer review

TY - GEN

T1 - High-throughput screening of cell-surface topographic interactions

AU - Unadkat, Hemant V.

AU - Hulsman, Marc

AU - Cornelissen, Kamiel

AU - Papenburg, Bernke

AU - Truckenmüller, Roman K.

AU - Post, Gerhard F.

AU - Uetz, Marc

AU - Reinders, Marcel J.T.

AU - Stamatialis, Dimitrios

AU - Van Blitterswijk, Clemens

AU - De Boer, Jan

N1 - Conference code: 14

PY - 2010/12/1

Y1 - 2010/12/1

N2 - High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

AB - High throughput biomaterials screening largely remains unexplored. The present study was an attempt to explore the area of high throughput as well as high content screening of cell surface topographic interaction. An array of surface topographies called TopoChip was fabricated using a widely used polymer in tissue engineering, Poly (DL-lactic acid). The topographies were subsequently screened for their mitogenic effect on cells. We were able to detect topographic parameters responsible for mitogenic effect of surface topographies.

KW - Biomaterials

KW - Cell behavior

KW - High-throughput screening

KW - Micro-nanotopographies

UR - http://www.scopus.com/inward/record.url?scp=84884336962&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84884336962

SN - 9781618390622

T3 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

SP - 2083

EP - 2084

BT - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

T2 - 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

Y2 - 3 October 2010 through 7 October 2010

ER -

Unadkat HV, Hulsman M, Cornelissen K, Papenburg B, Truckenmüller RK, Post GF et al. High-throughput screening of cell-surface topographic interactions. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. 2010. blz. 2083-2084. (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010).

High-throughput screening of cell-surface topographic interactions

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