High-speed narrow-bore capillary gas chromatography in combination with a fast and double-focusing mass spectrometer

P.G. Ysacker, van, J. Brown, J.G.M. Janssen, P.A. Leclercq, A. Phillips

Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

13 Citaten (Scopus)
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Samenvatting

In this work the application of high-speed narrow-bore capillary GC in combination with a fast scanning double focusing magnetic sector mass spectrometer is evaluated. Special emphasis is placed upon detection limits and scan speed in the full scan mode and in the selected ion monitoring mode (SIM). In the full scan mode, up to 20 scans per second could be obtained. The detection limits are in the low picogram range in the full scan mode and improve even to 5 to 50 fg in the SIM mode, depending on the sample complexity and mass resolving power. It will be illustrated that by increasing the resolution in the SIM mode, interferences from ions of the same nominal mass-to-charge ratio as the ions of interest are significantly reduced. Chemical background noise can therefore be largely eliminated, thus enhancing the signal-to-noise ratio.
Originele taal-2Engels
Pagina's (van-tot)517-524
Aantal pagina's8
TijdschriftJournal of High Resolution Chromatography
Volume18
Nummer van het tijdschrift9
DOI's
StatusGepubliceerd - 1995

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