Heart rate variability, sleep, and the early detection of post-traumatic stress disorder

Geert J.M. van Boxtel, Pierre J.M. Cluitmans, Roy J.E.M. Raymann, Martin Ouwerkerk, Ad J.M. Denissen, Marian K.J. Dekker, Margriet M. Sitskoorn

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

3 Citaties (Scopus)

Uittreksel

Measures of heart rate variability (HRV) are sensitive indices of autonomic nervous system functioning, capable of distinguishing activity of its two constituent branches, the sympathetic and parasympathetic nervous systems. As such, these measures are possibly useful as early markers of post-traumatic stress disorder (PTSD). We review the anatomical and physiological background of the cardiovascular system and provide guidelines for measuring the electrocardiogram and for deriving HRV measures. In addition, normative values for various HRV measures are provided, both in the time domain and in the frequency domain. We then review literature linking these HRV measures to PTSD, to sleep, and to the combination of PTSD and sleep. From this review, it appears that during awake resting states, PTSD patients are characterized by low parasympathetic tone, relative to healthy controls, resulting in elevated mean heart rates and reduced cardiac reactivity. By contrast, during sleep PTSD patients appear to be characterized by increased sympathetic activation, mainly observed during REM sleep, again with elevated mean heart rate and reduced reactivity as a consequence. We advocate the use of HRV measures in studies aimed at identifying individuals at risk for developing PTSD symptoms.

Originele taal-2Engels
TitelSleep and Combat-Related Post Traumatic Stress Disorder
RedacteurenE. Vermetten, A. Germain, T.C. Neylan
Plaats van productieDordrecht
UitgeverijSpringer
Pagina's253-263
Aantal pagina's11
ISBN van elektronische versie978-1-4939-7148-0
ISBN van geprinte versie978-1-4939-7146-6
DOI's
StatusGepubliceerd - 1 jan 2017

Vingerafdruk

Post-Traumatic Stress Disorders
Sleep
Heart Rate
Parasympathetic Nervous System
Autonomic Nervous System
Sympathetic Nervous System
REM Sleep
Cardiovascular System
Electrocardiography
Guidelines

Citeer dit

van Boxtel, G. J. M., Cluitmans, P. J. M., Raymann, R. J. E. M., Ouwerkerk, M., Denissen, A. J. M., Dekker, M. K. J., & Sitskoorn, M. M. (2017). Heart rate variability, sleep, and the early detection of post-traumatic stress disorder. In E. Vermetten, A. Germain, & T. C. Neylan (editors), Sleep and Combat-Related Post Traumatic Stress Disorder (blz. 253-263). Dordrecht: Springer. https://doi.org/10.1007/978-1-4939-7148-0_22
van Boxtel, Geert J.M. ; Cluitmans, Pierre J.M. ; Raymann, Roy J.E.M. ; Ouwerkerk, Martin ; Denissen, Ad J.M. ; Dekker, Marian K.J. ; Sitskoorn, Margriet M. / Heart rate variability, sleep, and the early detection of post-traumatic stress disorder. Sleep and Combat-Related Post Traumatic Stress Disorder. redacteur / E. Vermetten ; A. Germain ; T.C. Neylan. Dordrecht : Springer, 2017. blz. 253-263
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van Boxtel, GJM, Cluitmans, PJM, Raymann, RJEM, Ouwerkerk, M, Denissen, AJM, Dekker, MKJ & Sitskoorn, MM 2017, Heart rate variability, sleep, and the early detection of post-traumatic stress disorder. in E Vermetten, A Germain & TC Neylan (redactie), Sleep and Combat-Related Post Traumatic Stress Disorder. Springer, Dordrecht, blz. 253-263. https://doi.org/10.1007/978-1-4939-7148-0_22

Heart rate variability, sleep, and the early detection of post-traumatic stress disorder. / van Boxtel, Geert J.M.; Cluitmans, Pierre J.M.; Raymann, Roy J.E.M.; Ouwerkerk, Martin; Denissen, Ad J.M.; Dekker, Marian K.J.; Sitskoorn, Margriet M.

Sleep and Combat-Related Post Traumatic Stress Disorder. redactie / E. Vermetten; A. Germain; T.C. Neylan. Dordrecht : Springer, 2017. blz. 253-263.

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukAcademicpeer review

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AU - Ouwerkerk, Martin

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N2 - Measures of heart rate variability (HRV) are sensitive indices of autonomic nervous system functioning, capable of distinguishing activity of its two constituent branches, the sympathetic and parasympathetic nervous systems. As such, these measures are possibly useful as early markers of post-traumatic stress disorder (PTSD). We review the anatomical and physiological background of the cardiovascular system and provide guidelines for measuring the electrocardiogram and for deriving HRV measures. In addition, normative values for various HRV measures are provided, both in the time domain and in the frequency domain. We then review literature linking these HRV measures to PTSD, to sleep, and to the combination of PTSD and sleep. From this review, it appears that during awake resting states, PTSD patients are characterized by low parasympathetic tone, relative to healthy controls, resulting in elevated mean heart rates and reduced cardiac reactivity. By contrast, during sleep PTSD patients appear to be characterized by increased sympathetic activation, mainly observed during REM sleep, again with elevated mean heart rate and reduced reactivity as a consequence. We advocate the use of HRV measures in studies aimed at identifying individuals at risk for developing PTSD symptoms.

AB - Measures of heart rate variability (HRV) are sensitive indices of autonomic nervous system functioning, capable of distinguishing activity of its two constituent branches, the sympathetic and parasympathetic nervous systems. As such, these measures are possibly useful as early markers of post-traumatic stress disorder (PTSD). We review the anatomical and physiological background of the cardiovascular system and provide guidelines for measuring the electrocardiogram and for deriving HRV measures. In addition, normative values for various HRV measures are provided, both in the time domain and in the frequency domain. We then review literature linking these HRV measures to PTSD, to sleep, and to the combination of PTSD and sleep. From this review, it appears that during awake resting states, PTSD patients are characterized by low parasympathetic tone, relative to healthy controls, resulting in elevated mean heart rates and reduced cardiac reactivity. By contrast, during sleep PTSD patients appear to be characterized by increased sympathetic activation, mainly observed during REM sleep, again with elevated mean heart rate and reduced reactivity as a consequence. We advocate the use of HRV measures in studies aimed at identifying individuals at risk for developing PTSD symptoms.

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van Boxtel GJM, Cluitmans PJM, Raymann RJEM, Ouwerkerk M, Denissen AJM, Dekker MKJ et al. Heart rate variability, sleep, and the early detection of post-traumatic stress disorder. In Vermetten E, Germain A, Neylan TC, redacteurs, Sleep and Combat-Related Post Traumatic Stress Disorder. Dordrecht: Springer. 2017. blz. 253-263 https://doi.org/10.1007/978-1-4939-7148-0_22