Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

D. Abdurrachim, J.J.F.P. Luiken, K. Nicolay, J.F.C. Glatz, J.J. Prompers, M. Nabben

    Onderzoeksoutput: Bijdrage aan tijdschriftTijdschriftartikelAcademicpeer review

    59 Citaten (Scopus)
    3 Downloads (Pure)

    Samenvatting

    The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.

    Originele taal-2Engels
    Pagina's (van-tot)194-205
    Aantal pagina's12
    TijdschriftCardiovascular Research
    Volume106
    Nummer van het tijdschrift2
    DOI's
    StatusGepubliceerd - 1 mei 2015

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